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Science 8 June 1984:
Vol. 224. no. 4653, pp. 1109 - 1111
DOI: 10.1126/science.6372097
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Articles

Science, Vol 224, Issue 4653, 1109-1111
Copyright © 1984 by American Association for the Advancement of Science

articles

Saccharomyces cerevisiae produces a yeast substance that exhibits estrogenic activity in mammalian systems

D Feldman, PA Stathis, MA Hirst, EP Stover, and YS Do

Partially purified lipid extracts of Saccharomyces cerevisiae contain a substance that displaces tritiated estradiol from rat uterine cytosol estrogen receptors. The yeast product induces estrogenic bioresponses in mammalian systems as measured by induction of progesterone receptors in cultured MCF-7 human breast cancer cells and by a uterotrophic response and progesterone receptor induction after administration to ovariectomized mice. The findings raise the possibility that bakers' yeast may be a source of environmental estrogens.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)