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Science 8 June 1984:
Vol. 224. no. 4653, pp. 1102 - 1104
DOI: 10.1126/science.6144183
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Articles

Science, Vol 224, Issue 4653, 1102-1104
Copyright © 1984 by American Association for the Advancement of Science

articles

Impulse activity differentially regulates [Leu]enkephalin and catecholamine characters in the adrenal medulla

EF LaGamma, JE Adler, and IB Black

Regulation of the putative peptide neurohumour [Leu]enkephalin and the catecholaminergic enzymes tyrosine hydroxylase and phenylethanolamine-N-methyl-transferase was examined in the rat adrenal medulla in vivo and in vitro. Surgical denervation of the adrenal gland or pharmacologic blockade of synaptic transmission, treatments known to decrease catecholamine traits, increased [Leu]enkephalin content. Medullas explanted to culture exhibited a 50-fold rise in [Leu]enkephalin in 4 days, whereas tyrosine hydroxylase remained constant, and phenylethanolamine-N-methyltransferase decreased to a new baseline level. Veratridine-induced depolarization prevented the accumulation of [Leu]enkephalin, an effect that was blocked by tetrodotoxin, which antagonizes transmembrane Na+ influx. These studies suggest that enkephalinergic and catecholamine characters are differentially regulated by impulse activity and depolarization in the adrenal medulla.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Activity-dependent Regulation of Gene Expression in Adult Monkey Visual Cortex.
E.G. Jones, D.L. Benson, S.H.C. Hendry, and P.J. Isackson (1990)
Cold Spring Harb Symp Quant Biol 55, 481-490
   Abstract »    PDF »
Biochemistry of information storage in the nervous system.
I. Black, J. Adler, C. Dreyfus, W. Friedman, E. LaGamma, and A. Roach (1987)
Science 236, 1263-1268
   Abstract »    PDF »
Neurotransmitter plasticity at the molecular level.
I. Black, J. Adler, C. Dreyfus, G. Jonakait, D. Katz, E. LaGamma, and K. Markey (1984)
Science 225, 1266-1270
   Abstract »    PDF »


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