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Science 8 June 1984:
Vol. 224. no. 4653, pp. 1057 - 1063
DOI: 10.1126/science.6144182
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Articles

Science, Vol 224, Issue 4653, 1057-1063
Copyright © 1984 by American Association for the Advancement of Science

articles

The biochemistry of memory: a new and specific hypothesis

G Lynch and M Baudry

Recent studies have uncovered a synaptic process with properties required for an intermediate step in memory storage. Calcium rapidly and irreversibly increases the number of receptors for glutamate (a probable neurotransmitter) in forebrain synaptic membranes by activating a proteinase (calpain) that degrades fodrin, a spectrin-like protein. This process provides a means through which physiological activity could produce long-lasting changes in synaptic chemistry and ultrastructure. Since the process is only poorly represented in the brain stem, it is hypothesized to be responsible for those forms of memory localized in the telencephalon.


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