Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 1 June 1984:
Vol. 224. no. 4652, pp. 992 - 994
DOI: 10.1126/science.6326267
Prev | Table of Contents | Next

Articles

Science, Vol 224, Issue 4652, 992-994
Copyright © 1984 by American Association for the Advancement of Science

articles

Inhibition of aldosterone production by an atrial extract

K Atarashi, PJ Mulrow, R Franco-Saenz, R Snajdar, and J Rapp

Crude extracts of rat atria reduced the basal amount of aldosterone released from rat zona glomerulosa cells and partially inhibited aldosterone stimulation by adrenocorticotropic hormone and angiotensin II. The destruction of this activity by trypsin suggests that the active factor is a peptide, possibly atrial natriuretic factor. These data suggest that atrial natriuretic factor affects sodium excretion by the kidneys both directly and through the inhibition of aldosterone production.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A human atrial natriuretic peptide gene mutation reveals a novel peptide with enhanced blood pressure-lowering, renal-enhancing, and aldosterone-suppressing actions..
P. M. McKie, A. Cataliotti, B. K. Huntley, F. L. Martin, T. M. Olson, and J. C. Burnett Jr (2009)
J. Am. Coll. Cardiol. 54, 1024-1032
   Abstract »    Full Text »    PDF »
Natriuretic peptides and acute renal failure.
D. L. Vesely (2003)
Am J Physiol Renal Physiol 285, F167-F177
   Abstract »    Full Text »    PDF »
Aldosterone Is Produced From Ventricles in Patients With Essential Hypertension.
N. Yamamoto, H. Yasue, Y. Mizuno, M. Yoshimura, H. Fujii, M. Nakayama, E. Harada, S. Nakamura, T. Ito, and H. Ogawa (2002)
Hypertension 39, 958-962
   Abstract »    Full Text »    PDF »
Aldosterone Production Is Activated in Failing Ventricle in Humans.
Y. Mizuno, M. Yoshimura, H. Yasue, T. Sakamoto, H. Ogawa, K. Kugiyama, E. Harada, M. Nakayama, S. Nakamura, T. Ito, et al. (2001)
Circulation 103, 72-77
   Abstract »    Full Text »    PDF »
Interaction of angiotensin II and atrial natriuretic peptide on pHi regulation in MDCK cells.
M. Oliveira-Souza and M. De Mello-Aires (2000)
Am J Physiol Renal Physiol 279, F944-F953
   Abstract »    Full Text »    PDF »
Guanylyl Cyclases and Signaling by Cyclic GMP.
K. A. Lucas, G. M. Pitari, S. Kazerounian, I. Ruiz-Stewart, J. Park, S. Schulz, K. P. Chepenik, and S. A. Waldman (2000)
Pharmacol. Rev. 52, 375-414
   Abstract »    Full Text »    PDF »
Regulation of Natriuretic Peptide Receptors by Thyrotropin in FRTL-5 Rat Thyroid Cells: Evidence for Nonguanylate Cyclase Atrial Natriuretic Factor-Binding Sites in Cells Lacking the Natriuretic Peptide Receptor C.
D. F. Sellitti and S. Q. Doi (1999)
Endocrinology 140, 1365-1374
   Abstract »    Full Text »
Nitric Oxide Inhibits Aldosterone Synthesis by a Guanylyl Cyclase-Independent Effect.
C. J. Hanke, J. G. Drewett, C. R. Myers, and W. B. Campbell (1998)
Endocrinology 139, 4053-4060
   Abstract »    Full Text »    PDF »
Inhibition of Neutral Endopeptidase Causes Vasoconstriction of Human Resistance Vessels In Vivo.
C. J. Ferro, J. C. Spratt, W. G. Haynes, and D. J. Webb (1998)
Circulation 97, 2323-2330
   Abstract »    Full Text »    PDF »
Characterization of the Atrial Natriuretic Peptide System in the Oviduct.
S. H. Kim, K. W. Cho, S. Z. Kim, and G. Y. Koh (1997)
Endocrinology 138, 2410-2416
   Abstract »    Full Text »    PDF »
Inhibition of the T-Type Ca2+ Current by the Dopamine D1 Receptor in Rat Adrenal Glomerulosa Cells: Requirement of the Combined Action of the G{beta}{gamma} Protein Subunit and Cyclic Adenosine 3',5'-Monophosphate.
P. Drolet, L. Bilodeau, A. Chorvatova, L. Laflamme, N. Gallo-Payet, and M. D. Payet (1997)
Mol. Endocrinol. 11, 503-514
   Abstract »    Full Text »
The Atrial Natriuretic Peptide and Its Relation to Hemodynamic and Laboratory Values in Mitral Valve and Coronary Surgery.
M. Pac, A. Ates, H. Kocak, M.R. Yigitoglu, and I. Yekeler (1992)
Vascular and Endovascular Surgery 26, 109-115
   Abstract »    PDF »
Circulating atrial natriuretic peptides in conscious rats: regulation of release by multiple factors.
R Eskay, Z Zukowska-Grojec, M Haass, J. Dave, and N Zamir (1986)
Science 232, 636-639
   Abstract »    PDF »
Atrial natriuretic factor: a hormone produced by the heart.
A. de Bold (1985)
Science 230, 767-770
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)