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Science 1 June 1984:
Vol. 224. no. 4652, pp. 1014 - 1017
DOI: 10.1126/science.6426058
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Articles

Science, Vol 224, Issue 4652, 1014-1017
Copyright © 1984 by American Association for the Advancement of Science

articles

Toxicant-disease-environment interactions associated with suppression of immune system, growth, and reproduction

WP Porter, R Hinsdill, A Fairbrother, LJ Olson, J Jaeger, T Yuill, S Bisgaard, WG Hunter, and K Nolan

The effects of marginal malnourishment , infections, and environmental chemicals on growth and reproductive success in Swiss-Webster white mice and wild deer mice were studied with fractional factorial designs. Interaction effects were discovered. For example, malnourished mice were more sensitive to virus exposure and environmental chemicals (a plant growth regulator or polychlorinated biphenyls). Since several commercial plant growth regulators also appear to suppress the immune system, these results cast doubt on the adequacy of current toxicity testing procedures in which factors are studied individually and not in combination.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Endocrine, immune, and behavioral effects of aldicarb (carbamate), atrazine (triazine) and nitrate (fertilizer) mixtures at groundwater concentrations.
J. W. Jaeger, I. H. Carlson, and W. P. Porter (1999)
Toxicology and Industrial Health 15, 133-151
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