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Science 1 June 1984:
Vol. 224. no. 4652, pp. 1009 - 1011
DOI: 10.1126/science.6326265
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Articles

Science, Vol 224, Issue 4652, 1009-1011
Copyright © 1984 by American Association for the Advancement of Science

articles

Androgen modulation of adrenal angiotensin receptors

JE Carroll and TL Goodfriend

Several polar androgens increased the binding of angiotensin and its stimulation of aldosteronogenesis in bovine adrenal glomerulosa cells. The effect was seen only if the steroids were applied to the cells and then washed away. This phenomenon and the technique for demonstrating it may have implications for studies of receptor modulation and for clinical states in which responsiveness to angiotensin is increased.


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Effects of Dehydroepiandrosterone Sulfate on Cellular Calcium Responsiveness and Vascular Contractility.
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Identification of a cis-Acting Glucocorticoid Responsive Element in the Rat Angiotensin II Type 1A Promoter.
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