Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 1 June 1984:
Vol. 224. no. 4652, pp. 1007 - 1009
DOI: 10.1126/science.6426057
Prev | Table of Contents | Next

Articles

Science, Vol 224, Issue 4652, 1007-1009
Copyright © 1984 by American Association for the Advancement of Science

articles

Human monocytes activated by immunomodulators in liposomes lyse herpesvirus-infected but not normal cells

WC Koff, IJ Fidler, SD Showalter, MK Chakrabarty, B Hampar, LM Ceccorulli, and ES Kleinerman

Highly purified peripheral blood monocytes from normal human donors were activated in vitro by incubation with liposomes containing immunomodulators such as recombinant human gamma interferon, human lymphokines, or muramyl dipeptide. The ability of liposomes containing immunomodulators to activate monocytes to a cytotoxic state capable of discriminating between virus-infected and uninfected cells was shown by activated monocytes recognizing and destroying herpes simplex virus type 2-infected cells while leaving uninfected cells unharmed .


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Macrophage Activation by Poly(maleic acid-alt-2-cyclohexyl-1,3-dioxap-5-ene) Encapsulated in Polysaccharide-Coated Liposomes.
T. Sato, K. Kojima, T.-A. Ihda, J. Sunamoto, and R. M. Ottenbrite (1986)
Journal of Bioactive and Compatible Polymers 1, 448-460
   Abstract »    PDF »
Protection of mice against fatal herpes simplex type 2 infection by liposomes containing muramyl tripeptide.
W. Koff, S. Showalter, B Hampar, and I. Fidler (1985)
Science 228, 495-497
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)