Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 1 June 1984:
Vol. 224. no. 4652, pp. 1001 - 1004
DOI: 10.1126/science.6372092
Prev | Table of Contents | Next

Articles

Science, Vol 224, Issue 4652, 1001-1004
Copyright © 1984 by American Association for the Advancement of Science

articles

The respiratory sinus arrhythmia: a measure of cardiac age

WJ Hrushesky, D Fader, O Schmitt, and V Gilbertsen

A method developed for quantifying respiratory sinus arrhythmia (RSA) during voluntary cardiorespiratory synchronization relies on computer-assisted rhythmometric cosinor analysis of instantaneous heart rate data. The RSA was present in all subjects tested, even those at advanced ages. The amplitude of the RSA falls approximately 10 percent per decade. An individual with a transplanted heart and one with severe diabetic neuropathy each had resting RSA values that were normal for their ages. The shape and amplitude of the RSA during voluntary cardiorespiratory synchronization may reflect the suppleness of the heart and its response to rhythmically changing intrathoracic pressure and the subsequent ebb-and-flow of venous return. Our technology allows objective quantitative assessment of the biologic age of the heart and also the effect of any drug, disease, or behavior that affects the RSA.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Autonomic modulation in patients with congenital generalized lipodystrophy (Berardinelli-Seip syndrome).
C. A. Faria, R. S. Moraes, D. C. Sobral-Filho, A. G. Rego, M. F.P. Baracho, E. S.T. Egito, and J. Brandao-Neto (2009)
Europace 11, 763-769
   Abstract »    Full Text »    PDF »
Heart Rate Variability and Obesity Indices: Emphasis on the Response to Noise and Standing.
J. A Kim, Y.-G. Park, K.-H. Cho, M.-H. Hong, H.-C. Han, Y.-S. Choi, and D. Yoon (2005)
J Am Board Fam Med 18, 97-103
   Abstract »    Full Text »    PDF »
Respiratory Sinus Arrhythmia: Why Does the Heartbeat Synchronize With Respiratory Rhythm?.
F. Yasuma and J.-i. Hayano (2004)
Chest 125, 683-690
   Abstract »    Full Text »    PDF »
Hypothesis: respiratory sinus arrhythmia is an intrinsic resting function of cardiopulmonary system.
J. Hayano and F. Yasuma (2003)
Cardiovasc Res 58, 1-9
   Abstract »    Full Text »    PDF »
Sympathetic restraint of respiratory sinus arrhythmia: implications for vagal-cardiac tone assessment in humans.
J. A. Taylor, C. W. Myers, J. R. Halliwill, H. Seidel, and D. L. Eckberg (2001)
Am J Physiol Heart Circ Physiol 280, H2804-H2814
   Abstract »    Full Text »    PDF »
Temporally localized contributions to measures of large-scale heart rate variability.
D. Roach, A. Sheldon, W. Wilson, and R. Sheldon (1998)
Am J Physiol Heart Circ Physiol 274, H1465-H1471
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)