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Science 25 May 1984:
Vol. 224. no. 4651, pp. 901 - 903
DOI: 10.1126/science.6719123
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Articles

Science, Vol 224, Issue 4651, 901-903
Copyright © 1984 by American Association for the Advancement of Science

articles

Forebrain lesions disrupt development but not maintenance of song in passerine birds

SW Bottjer, EA Miesner, and AP Arnold

The magnocellular nucleus of the anterior neostriatum is a forebrain nucleus of passerine birds that accumulates testosterone and makes monosynaptic connections with other telencephalic nuclei that control song production in adult birds. Lesions in the magnocellular nucleus disrupted song development in juvenile male zebra finches but did not affect maintenance of stable song patterns by adult birds. These results represent an instance in which lesions of a discrete brain region during only a restricted phase in the development of a learned behavior cause permanent impairment. Because cells of the magnocellular nucleus accumulate androgens these findings raise the possibility that this learning is mediated by hormones.


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F. Nottebohm (2002)
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Development of Individual Axon Arbors in a Thalamocortical Circuit Necessary for Song Learning in Zebra Finches.
S. Iyengar and S. W. Bottjer (2002)
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Auditory representation of the vocal repertoire in a songbird with multiple song types.
R. Mooney, W. Hoese, and S. Nowicki (2001)
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M. Luo, L. Ding, and D. J. Perkel (2001)
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Zebra Finch CB1 Cannabinoid Receptor: Pharmacology and in Vivo and in Vitro Effects of Activation.
K. Soderstrom and F. Johnson (2001)
J. Pharmacol. Exp. Ther. 297, 189-197
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Postlearning Consolidation of Birdsong: Stabilizing Effects of Age and Anterior Forebrain Lesions.
M. S. Brainard and A. J. Doupe (2001)
J. Neurosci. 21, 2501-2517
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Androgens and Isolation From Adult Tutors Differentially Affect the Development of Songbird Neurons Critical to Vocal Plasticity.
F. S. Livingston and R. Mooney (2001)
J Neurophysiol 85, 34-42
   Abstract »    Full Text »    PDF »
Slow Synaptic Inhibition Mediated by Metabotropic Glutamate Receptor Activation of GIRK Channels.
P. Dutar, J. J. Petrozzino, H. M. Vu, M. F. Schmidt, and D. J. Perkel (2000)
J Neurophysiol 84, 2284-2290
   Abstract »    Full Text »    PDF »
Song selectivity and sensorimotor signals in vocal learning and production.
M. M. Solis, M. S. Brainard, N. A. Hessler, and A. J. Doupe (2000)
PNAS 97, 11836-11842
   Abstract »    Full Text »    PDF »
An Associational Model of Birdsong Sensorimotor Learning I. Efference Copy and the Learning of Song Syllables.
T. W. Troyer and A. J. Doupe (2000)
J Neurophysiol 84, 1204-1223
   Abstract »    Full Text »    PDF »
Gene Expression and Synaptic Plasticity in the Auditory Forebrain of Songbirds.
S. Ribeiro and C.V. Mello (2000)
Learn. Mem. 7, 235-243
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Different Subthreshold Mechanisms Underlie Song Selectivity in Identified HVc Neurons of the Zebra Finch.
R. Mooney (2000)
J. Neurosci. 20, 5420-5436
   Abstract »    Full Text »    PDF »
Intrinsic and Extrinsic Contributions to Auditory Selectivity in a Song Nucleus Critical for Vocal Plasticity.
M. J. Rosen and R. Mooney (2000)
J. Neurosci. 20, 5437-5448
   Abstract »    Full Text »    PDF »
Singing in the brain.
P. Marler and A. J. Doupe (2000)
PNAS 97, 2965-2967
   Full Text »    PDF »
Singing-Related Neural Activity in a Dorsal Forebrain-Basal Ganglia Circuit of Adult Zebra Finches.
N. A. Hessler and A. J. Doupe (1999)
J. Neurosci. 19, 10461-10481
   Abstract »    Full Text »    PDF »
Androgens Modulate NMDA Receptor-Mediated EPSCs in the Zebra Finch Song System.
S. A. White, F. S. Livingston, and R. Mooney (1999)
J Neurophysiol 82, 2221-2234
   Abstract »    Full Text »    PDF »
Lesions of an Avian Forebrain Nucleus That Disrupt Song Development Alter Synaptic Connectivity and Transmission in the Vocal Premotor Pathway.
J. M. Kittelberger and R. Mooney (1999)
J. Neurosci. 19, 9385-9398
   Abstract »    Full Text »    PDF »
Two-Stage, Input-Specific Synaptic Maturation in a Nucleus Essential for Vocal Production in the Zebra Finch.
L. L. Stark and D. J. Perkel (1999)
J. Neurosci. 19, 9107-9116
   Abstract »    Full Text »    PDF »
A GABAergic, Strongly Inhibitory Projection to a Thalamic Nucleus in the Zebra Finch Song System.
M. Luo and D. J. Perkel (1999)
J. Neurosci. 19, 6700-6711
   Abstract »    Full Text »    PDF »
Development of Topography within Song Control Circuitry of Zebra Finches during the Sensitive Period for Song Learning.
S. Iyengar, S. S. Viswanathan, and S. W. Bottjer (1999)
J. Neurosci. 19, 6037-6057
   Abstract »    Full Text »    PDF »
Long-Range Inhibition Within the Zebra Finch Song Nucleus RA Can Coordinate the Firing of Multiple Projection Neurons.
J. E. Spiro, M. B. Dalva, and R. Mooney (1999)
J Neurophysiol 81, 3007-3020
   Abstract »    Full Text »    PDF »
Contributions of Tutor and Bird's Own Song Experience to Neural Selectivity in the Songbird Anterior Forebrain.
M. M. Solis and A. J. Doupe (1999)
J. Neurosci. 19, 4559-4584
   Abstract »    Full Text »    PDF »
Song-Induced Phosphorylation of cAMP Response Element-Binding Protein in the Songbird Brain.
H. Sakaguchi, K. Wada, M. Maekawa, T. Watsuji, and M. Hagiwara (1999)
J. Neurosci. 19, 3973-3981
   Abstract »    Full Text »    PDF »
Contributions of Social Cues and Photoperiod to Seasonal Plasticity in the Adult Avian Song Control System.
A. D. Tramontin, J. C. Wingfield, and E. A. Brenowitz (1999)
J. Neurosci. 19, 476-483
   Abstract »    Full Text »    PDF »
Behavioral State Modulation of Auditory Activity in a Vocal Motor System.
A. S. Dave, A. C. Yu, and D. Margoliash (1998)
Science 282, 2250-2254
   Abstract »    Full Text »
Transient expression and transport of brain-derived neurotrophic factor in the male zebra finch's song system during vocal development.
E. Akutagawa and M. Konishi (1998)
PNAS 95, 11429-11434
   Abstract »    Full Text »    PDF »
Intrinsic and Thalamic Excitatory Inputs Onto Songbird LMAN Neurons Differ in Their Pharmacological and Temporal Properties.
C. A. Boettiger and A. J. Doupe (1998)
J Neurophysiol 79, 2615-2628
   Abstract »    Full Text »    PDF »
Development of Intrinsic and Synaptic Properties in a Forebrain Nucleus Essential to Avian Song Learning.
F. S. Livingston and R. Mooney (1997)
J. Neurosci. 17, 8997-9009
   Abstract »    Full Text »    PDF »
Anterior Forebrain Neurons Develop Selectivity by an Intermediate Stage of Birdsong Learning.
M. M. Solis and A. J. Doupe (1997)
J. Neurosci. 17, 6447-6462
   Abstract »    Full Text »    PDF »
Motor-driven gene expression.
E. D. Jarvis and F. Nottebohm (1997)
PNAS 94, 4097-4102
   Abstract »    Full Text »    PDF »
Song- and Order-Selective Neurons in the Songbird Anterior Forebrain and their Emergence during Vocal Development.
A. J. Doupe (1997)
J. Neurosci. 17, 1147-1167
   Abstract »    Full Text »    PDF »
Intracellular Characterization of Song-Specific Neurons in the Zebra Finch Auditory Forebrain.
M. S. Lewicki (1996)
J. Neurosci. 16, 5854-5863
   Abstract »    Full Text »    PDF »
Auditory responses in avian vocal motor neurons: a motor theory for song perception in birds.
H Williams and F Nottebohm (1985)
Science 229, 279-282
   Abstract »    PDF »
From the Cover: Localized neuronal activation in the zebra finch brain is related to the strength of song learning.
J. J. Bolhuis, G. G. O. Zijlstra, A. M. den Boer-Visser, and E. A. Van der Zee (2000)
PNAS 97, 2282-2285
   Abstract »    Full Text »    PDF »
A relationship between behavior, neurotrophin expression, and new neuron survival.
X.-C. Li, E. D. Jarvis, B. Alvarez-Borda, D. A. Lim, and F. Nottebohm (2000)
PNAS 97, 8584-8589
   Abstract »    Full Text »    PDF »


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