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Science 25 May 1984:
Vol. 224. no. 4651, pp. 884 - 886
DOI: 10.1126/science.6719117
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Articles

Science, Vol 224, Issue 4651, 884-886
Copyright © 1984 by American Association for the Advancement of Science

articles

Reactive metabolites from the bioactivation of toxic methylfurans

V Ravindranath, LT Burka, and MR Boyd

An important mechanism of toxicity of furans involves the cytochrome P-450 monooxygenase-catalyzed bioactivation of the compound in situ directly within the target tissues to highly reactive electrophilic products. The unsaturated aldehydes acetylacrolein and methylbutenedial have been identified as the principal reactive intermediates of 2- and 3-methylfuran, respectively, that are produced and bound covalently to tissue macromolecules in hepatic and pulmonary microsomal systems in vitro.


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Drug Metab. Dispos. 32, 1345-1350
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Chemically Reactive Intermediates and Pulmonary Xenobiotic Toxicity.
T. E. Gram (1997)
Pharmacol. Rev. 49, 297-342
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The Role of Metabolism in Chemical-Induced Pulmonary Toxicity*1.
B. R. Smith and W. R. Brian (1991)
Toxicol Pathol 19, 470-481
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