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Science 11 May 1984:
Vol. 224. no. 4649, pp. 627 - 630
DOI: 10.1126/science.6324350
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Articles

Science, Vol 224, Issue 4649, 627-630
Copyright © 1984 by American Association for the Advancement of Science

articles

Long-term potentiation of hippocampal synaptic transmission affects rate of behavioral learning

TW Berger

Electrical stimulation techniques were used to produce a long-lasting potentiation of synaptic transmission in the hippocampus of naive rabbits. Animals were then classically conditioned. Long-term potentiation of the hippocampus before training increased the rate at which animals subsequently learned the conditioning task. This result has significance for potential cellular mechanisms of associative learning.


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