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Science 11 May 1984:
Vol. 224. no. 4649, pp. 622 - 625
DOI: 10.1126/science.6231726
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Articles

Science, Vol 224, Issue 4649, 622-625
Copyright © 1984 by American Association for the Advancement of Science

articles

A potential second messenger role for unsaturated fatty acids: activation of Ca2+-dependent protein kinase

LC McPhail, CC Clayton, and R Snyderman

Arachidonate and other unsaturated long-chain fatty acids were found to activate protein kinase C from human neutrophils. Kinase activation by arachidonate required calcium and was enhanced by diolein but did not require exogenous phosphatidylserine. Submaximal levels of arachidonate also enhanced the affinity of the kinase for calcium during activation by phosphatidylserine. Thus the release of arachidonate, which is triggered in many cell types by ligand-receptor interactions, could play a second messenger role in the regulation of cellular function by activation of protein kinase C.


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