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Science 11 May 1984:
Vol. 224. no. 4649, pp. 617 - 619
DOI: 10.1126/science.6200940
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Articles
Science, Vol 224, Issue 4649, 617-619
Copyright © 1984 by American Association for the Advancement of Science
Arabinosylcytosine induces fetal hemoglobin in baboons by perturbing erythroid cell differentiation kinetics
T Papayannopoulou,
A Torrealba de Ron,
R Veith,
G Knitter,
and
G Stamatoyannopoulos
Arabinosylcytosine, a compound that inhibits DNA synthesis in rapidly dividing cells, stimulates fetal hemoglobin in adult baboons and produces significant perturbations in the pools of erythroid progenitors. It appears that changes in the kinetics of erythroid cell differentiation rather than direct action on the gamma genes underlie stimulation of fetal hemoglobin in the adult animals in vivo. These results also suggest that chemotherapeutic agents selected for their low carcinogenic or mutagenic potential could be used for therapeutic induction of fetal hemoglobin in patients with sickle cell anemia.
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- Effect of Hydroxyurea on the Frequency of Painful Crises in Sickle Cell Anemia.
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