Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 11 May 1984:
Vol. 224. no. 4649, pp. 612 - 615
DOI: 10.1126/science.6710160
Prev | Table of Contents | Next

Articles

Science, Vol 224, Issue 4649, 612-615
Copyright © 1984 by American Association for the Advancement of Science

articles

Differential NK cell and macrophage killing of hamster cells infected with nononcogenic or oncogenic adenovirus

JL Cook and AM Lewis Jr

Hamster cells infected with highly oncogenic human adenovirus type 12 (Ad12) were resistant to lysis by natural killer cells and macrophages, compared to cells infected with nononcogenic adenovirus type 2 (Ad2). The data suggest that early adenovirus gene expression in hamster cells results in preferential survival of Ad12, compared to Ad2, infected cells in vivo, thus providing an explanation for the differences in the oncogenicities of these two transforming viruses.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Role of Mouse Adenovirus Type 1 Early Region 1A in Acute and Persistent Infections in Mice.
K. Smith, C. C. Brown, and K. R. Spindler (1998)
J. Virol. 72, 5699-5706
   Abstract »    Full Text »    PDF »
Role of p300-family proteins in E1A oncogene induction of cytolytic susceptibility and tumor cell rejection.
J. L. Cook, C. K. Krantz, and B. A. Routes (1996)
PNAS 93, 13985-13990
   Abstract »    Full Text »    PDF »
Primary rat embryo cells transformed by one or two oncogenes show different metastatic potentials.
R Pozzatti, R Muschel, J Williams, R Padmanabhan, B Howard, L Liotta, and G Khoury (1986)
Science 232, 223-227
   Abstract »    PDF »
A new role for DNA virus early proteins in viral carcinogenesis.
A. Lewis Jr and J. Cook (1985)
Science 227, 15-20
   Abstract »    PDF »


ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)