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Science 11 May 1984:
Vol. 224. no. 4649, pp. 607 - 610
DOI: 10.1126/science.6324349
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Articles

Science, Vol 224, Issue 4649, 607-610
Copyright © 1984 by American Association for the Advancement of Science

articles

Antigens on HTLV-infected cells recognized by leukemia and AIDS sera are related to HTLV viral glycoprotein

J Schupbach, MG Sarngadharan, and RC Gallo

Cross-reactive antigens of molecular size of 61,000 to 68,000 daltons are found on the surface of human cells infected by human T-cell leukemia-lymphoma virus (HTLV). They are recognized by antibodies from patients with adult T-cell leukemias and lymphomas, from healthy carriers of HTLV, and from patients with the acquired immunodeficiency syndrome (AIDS). The latter finding has been one of the major reasons for suggesting an association of HTLV with AIDS. However, whether these antigens are of cellular or viral origin has not been clear. These antigens have now been shown to be associated with the presence of viral proteins in the cells, and a cross-reactive glycoprotein of molecular size of 46,000 daltons has been found to be a consistent structural part of viruses purified from several HTLV-producer cell lines. The findings thus suggest a viral (HTLV) origin of these antigens.


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