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Science 11 May 1984:
Vol. 224. no. 4649, pp. 605 - 607
DOI: 10.1126/science.6369541
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Articles

Science, Vol 224, Issue 4649, 605-607
Copyright © 1984 by American Association for the Advancement of Science

articles

Suppression of prolactin in pigs by Escherichia coli endotoxin

BB Smith and WC Wagner

An endotoxin produced by Escherichia coli caused a decrease in prolactin concentrations in the plasma of sows when given at low dosages 2 days postpartum. Five to tenfold increases occurred in the plasma cortisol concentrations. Piglet growth, used as an indicator of milk secretion by the sows, was significantly depressed after the endotoxin administration. Some cases of lactation failure in the periparturient sow may thus be due to endotoxins suppressing prolactin concentrations. This appears to be the first report of a bacterial endotoxin having an effect on prolactin in any species.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Tissue-specific gene expression of prolactin receptor in the acute-phase response induced by lipopolysaccharides.
A. M. Corbacho, G. Valacchi, L. Kubala, E. Olano-Martin, B. C. Schock, T. P. Kenny, and C. E. Cross (2004)
Am J Physiol Endocrinol Metab 287, E750-E757
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Science. ISSN 0036-8075 (print), 1095-9203 (online)