Science 11 May 1984: Vol. 224. no. 4649, pp. 569 - 573 DOI: 10.1126/science.6710156

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Articles

Dietary Intake of Vegetables and Fruits and the Modification Effects of GSTM1 and NAT2 Genotypes on Bladder Cancer Risk.

J. Lin, A. Kamat, J. Gu, M. Chen, C. P. Dinney, M. R. Forman, and X. Wu (2009)
Cancer Epidemiol. Biomarkers Prev. 18, 2090-2097
 |  Abstract »  |  Full Text »  |  PDF »

The Effects of Tomato Powder Supplementation on Performance and Lipid Peroxidation in Quail.

N. Sahin, C. Orhan, M. Tuzcu, K. Sahin, and O. Kucuk (2008)
Poult. Sci. 87, 276-283
 |  Abstract »  |  Full Text »  |  PDF »

Efficacy of Antioxidant Supplementation in Reducing Primary Cancer Incidence and Mortality: Systematic Review and Meta-analysis.

A. Bardia, I. M. Tleyjeh, J. R. Cerhan, A. K. Sood, P. J. Limburg, P. J. Erwin, and V. M. Montori (2008)
Mayo Clin. Proc. 83, 23-34
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Role of Oxidants and Antioxidants in Atherosclerosis: Results of In Vitro and In Vivo Investigations.

R. Siekmeier, C. Steffen, and W. Marz (2007)
Journal of Cardiovascular Pharmacology and Therapeutics 12, 265-282
 |  Abstract »  |  PDF »

{beta}-Carotene Inhibits Tumor-Specific Angiogenesis by Altering the Cytokine Profile and Inhibits the Nuclear Translocation of Transcription Factors in B16F-10 Melanoma Cells.

C. Guruvayoorappan and G. Kuttan (2007)
Integr Cancer Ther 6, 258-270
 |  Abstract »  |  PDF »

Effect of the Carotenoid-Producing Alga, Dunaliella bardawil, on CCl4-Induced Toxicity in Rats.

A. Vanitha, K. N. Chidambara Murthy, V. Kumar, G. Sakthivelu, J. M. Veigas, P. Saibaba, and G. A. Ravishankar (2007)
International Journal of Toxicology 26, 159-167
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The Arabidopsis aba4-1 Mutant Reveals a Specific Function for Neoxanthin in Protection against Photooxidative Stress.

L. Dall'Osto, S. Cazzaniga, H. North, A. Marion-Poll, and R. Bassi (2007)
PLANT CELL 19, 1048-1064
 |  Abstract »  |  Full Text »  |  PDF »

Dual role of {beta}-carotene in combination with cigarette smoke aqueous extract on the formation of mutagenic lipid peroxidation products in lung membranes: dependence on pO2.

P. Palozza, S. Serini, S. Trombino, L. Lauriola, F.O. Ranelletti, and G. Calviello (2006)
Carcinogenesis 27, 2383-2391
 |  Abstract »  |  Full Text »  |  PDF »

Do carotenoid-based sexual traits signal the availability of non-pigmentary antioxidants?.

S. Bertrand, B. Faivre, and G. Sorci (2006)
J. Exp. Biol. 209, 4414-4419
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of chemically-induced neoplastic transformation by a novel tetrasodium diphosphate astaxanthin derivative.

L. M. Hix, D. A. Frey, M. D. McLaws, M. Osterlie, S. F. Lockwood, and J. S. Bertram (2005)
Carcinogenesis 26, 1634-1641
 |  Abstract »  |  Full Text »  |  PDF »

Lycopene Inhibits Cell Migration and Invasion and Upregulates Nm23-H1 in a Highly Invasive Hepatocarcinoma, SK-Hep-1 Cells.

C.-S. Huang, M.-K. Shih, C.-H. Chuang, and M.-L. Hu (2005)
J. Nutr. 135, 2119-2123
 |  Abstract »  |  Full Text »  |  PDF »

Reassessment of a Free Radical Theory of Cancer With Emphasis on Ultraviolet Carcinogenesis.

H. S. Black (2004)
Integr Cancer Ther 3, 279-293
 |  Abstract »  |  PDF »

Dietary Carotenoids and Genetic Instability Modify Bladder Cancer Risk.

M. B. Schabath, H. B. Grossman, G. L. Delclos, L. M. Hernandez, R. S. Day, B. R. Davis, S. P. Lerner, M. R. Spitz, and X. Wu (2004)
J. Nutr. 134, 3362-3369
 |  Abstract »  |  Full Text »  |  PDF »

The SU.VI.MAX Study: A Randomized, Placebo-Controlled Trial of the Health Effects of Antioxidant Vitamins and Minerals.

S. Hercberg, P. Galan, P. Preziosi, S. Bertrais, L. Mennen, D. Malvy, A.-M. Roussel, A. Favier, and S. Briancon (2004)
Arch Intern Med 164, 2335-2342
 |  Abstract »  |  Full Text »  |  PDF »

Effects of oral vitamin E and {beta}-carotene supplementation on ultraviolet radiation-induced oxidative stress in human skin.

F. McArdle, L. E Rhodes, R. A. Parslew, G. L Close, C. I. Jack, P. S Friedmann, and M. J Jackson (2004)
Am. J. Clinical Nutrition 80, 1270-1275
 |  Abstract »  |  Full Text »  |  PDF »

Role of Oxidative Modifications in Atherosclerosis.

R. Stocker and J. F. Keaney Jr. (2004)
Physiol Rev 84, 1381-1478
 |  Abstract »  |  Full Text »  |  PDF »

{beta}-Carotene exacerbates DNA oxidative damage and modifies p53-related pathways of cell proliferation and apoptosis in cultured cells exposed to tobacco smoke condensate.

P. Palozza, S. Serini, F. Di Nicuolo, A. Boninsegna, A. Torsello, N. Maggiano, F. O. Ranelletti, F. I. Wolf, G. Calviello, and A. Cittadini (2004)
Carcinogenesis 25, 1315-1325
 |  Abstract »  |  Full Text »  |  PDF »

The Enigma of {beta}-Carotene in Carcinogenesis: What Can Be Learned from Animal Studies.

R. M. Russell (2004)
J. Nutr. 134, 262S-268
 |  Abstract »  |  Full Text »  |  PDF »

Antioxidant Intake and Primary Open-Angle Glaucoma: A Prospective Study.

J. H. Kang, L. R. Pasquale, W. Willett, B. Rosner, K. M. Egan, N. Faberowski, and S. E. Hankinson (2003)
Am. J. Epidemiol. 158, 337-346
 |  Abstract »  |  Full Text »  |  PDF »

Neoplastic and Antineoplastic Effects of {beta}-Carotene on Colorectal Adenoma Recurrence: Results of a Randomized Trial.

J. A. Baron, B. F. Cole, L. Mott, R. Haile, M. Grau, T. R. Church, G. J. Beck, and E. R. Greenberg (2003)
J Natl Cancer Inst 95, 717-722
 |  Abstract »  |  Full Text »  |  PDF »

Drought-Induced Changes in the Redox State of alpha -Tocopherol, Ascorbate, and the Diterpene Carnosic Acid in Chloroplasts of Labiatae Species Differing in Carnosic Acid Contents.

S. Munne-Bosch and L. Alegre (2003)
Plant Physiology 131, 1816-1825
 |  Abstract »  |  Full Text »  |  PDF »

A Randomized Trial of Beta Carotene and Age-Related Cataract in US Physicians.

W. G. Christen, J. E. Manson, R. J. Glynn, J. M. Gaziano, R. D. Sperduto, J. E. Buring, and C. H. Hennekens (2003)
Arch Ophthalmol 121, 372-378
 |  Abstract »  |  Full Text »  |  PDF »

{beta}-Carotene Regulates NF-{kappa}B DNA-Binding Activity by a Redox Mechanism in Human Leukemia and Colon Adenocarcinoma Cells.

P. Palozza, S. Serini, A. Torsello, F. Di Nicuolo, E. Piccioni, V. Ubaldi, C. Pioli, F. I. Wolf, and G. Calviello (2003)
J. Nutr. 133, 381-388
 |  Abstract »  |  Full Text »  |  PDF »

Detection of 2,6-Cyclolycopene-1,5-diol in Breast Nipple Aspirate Fluids and Plasma: A Potential Marker of Oxidative Stress.

G. Chen and Z. Djuric (2002)
Cancer Epidemiol. Biomarkers Prev. 11, 1592-1596
 |  Abstract »  |  Full Text »  |  PDF »

Dietary Carotenoids Contribute to Normal Human Skin Color and UV Photosensitivity.

S. Alaluf, U. Heinrich, W. Stahl, H. Tronnier, and S. Wiseman (2002)
J. Nutr. 132, 399-403
 |  Abstract »  |  Full Text »  |  PDF »

Induction of cytochrome P450 enzymes and over-generation of oxygen radicals in beta-carotene supplemented rats.

M. Paolini, A. Antelli, L. Pozzetti, D. Spetlova, P. Perocco, L. Valgimigli, G. F. Pedulli, and G. Cantelli-Forti (2001)
Carcinogenesis 22, 1483-1495
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Why don't we give chest patients dietary advice?.

G Devereux and A Seaton (2001)
Thorax 56, ii15-22
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Interactions of {beta}-carotene and cigarette smoke in human bronchial epithelial cells.

A. Arora, C. A. Willhite, and D. C. Liebler (2001)
Carcinogenesis 22, 1173-1178
 |  Abstract »  |  Full Text »  |  PDF »

Mapping the interactions between flavodoxin and its physiological partners flavodoxin reductase and cobalamin-dependent methionine synthase.

D. A. Hall, C. W. Vander Kooi, C. N. Stasik, S. Y. Stevens, E. R. P. Zuiderweg, and R. G. Matthews (2001)
PNAS
 |  Abstract »  |  Full Text »  |  PDF »

Highly selective water channel activity measured by voltage clamp: Analysis of planar lipid bilayers reconstituted with purified AqpZ.

P. Pohl, S. M. Saparov, M. J. Borgnia, and P. Agre (2001)
PNAS
 |  Abstract »  |  Full Text »  |  PDF »

Toxicity of {beta}-carotene and its exacerbation by acetaldehyde in HepG2 cells.

R. Ni, M. A. Leo, J. Zhao, and C. S. Lieber (2001)
Alcohol Alcohol. 36, 281-285
 |  Abstract »  |  Full Text »  |  PDF »

Maternally derived androgens and antioxidants in bird eggs: complementary but opposing effects?.

N. J. Royle, P. F. Surai, and I. R. Hartley (2001)
Behav. Ecol. 12, 381-385
 |  Abstract »  |  Full Text »  |  PDF »

Neonatal Chronic Lung Disease.

M. Avent, D. Coile, and L. Mathai (2001)
Journal of Pharmacy Practice 14, 181-206
 |  Abstract »  |  PDF »

The Color Difference in Orbital Fat.

B. S. Sires, J. C. Saari, G. G. Garwin, J. S. Hurst, and F. J. G. M. van Kuijk (2001)
Arch Ophthalmol 119, 868-871
 |  Abstract »  |  Full Text »  |  PDF »

Dietary Tomato Paste Protects against Ultraviolet Light-Induced Erythema in Humans.

W. Stahl, U. Heinrich, S. Wiseman, O. Eichler, H. Sies, and H. Tronnier (2001)
J. Nutr. 131, 1449-1451
 |  Abstract »  |  Full Text »

In Vitro Inhibition of Proliferation of Estrogen-Dependent and Estrogen-Independent Human Breast Cancer Cells Treated with Carotenoids or Retinoids.

P. Prakash, R. M. Russell, and N. I. Krinsky (2001)
J. Nutr. 131, 1574-1580
 |  Abstract »  |  Full Text »

Randomized Phase III Intergroup Trial of Isotretinoin to Prevent Second Primary Tumors in Stage I Non-Small-Cell Lung Cancer.

S. M. Lippman, J. J. Lee, D. D. Karp, E. E. Vokes, S. E. Benner, G. E. Goodman, F. R. Khuri, R. Marks, R. J. Winn, W. Fry, et al. (2001)
J Natl Cancer Inst 93, 605-618
 |  Abstract »  |  Full Text »  |  PDF »

Retinoids : Versatile Biological Response Modifiers of Vascular Smooth Muscle Phenotype.

J. M. Miano and B. C. Berk (2000)
Circ. Res. 87, 355-362
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Prevention of N-Methylnitrosourea-Induced Colon Carcinogenesis in Rats by Oxygenated Carotenoid Capsanthin and Capsanthin-Rich Paprika Juice.

T. Narisawa, Y. Fukaura, M. Hasebe, S. Nomura, S. Oshima, and T. Inakuma (2000)
Experimental Biology and Medicine 224, 116-122
 |  Abstract »  |  Full Text »

Tissue Distribution of Lycopene in Ferrets and Rats after Lycopene Supplementation.

A. L. A. Ferreira, K.-J. Yeum, C. Liu, D. Smith, N. I. Krinsky, X.-D. Wang, and R. M. Russell (2000)
J. Nutr. 130, 1256-1260
 |  Abstract »  |  Full Text »

Canthaxanthin Supplementation Alters Antioxidant Enzymes and Iron Concentration in Liver of Balb/c Mice.

P. Palozza, G. Calviello, M. Emilia De Leo, S. Serini, and G. M. Bartoli (2000)
J. Nutr. 130, 1303-1308
 |  Abstract »  |  Full Text »

Plasma Xanthophyll Carotenoids Correlate Inversely with Indices of Oxidative DNA Damage and Lipid Peroxidation.

A. D. Haegele, C. Gillette, C. O’Neill, P. Wolfe, J. Heimendinger, S. Sedlacek, and H. J. Thompson (2000)
Cancer Epidemiol. Biomarkers Prev. 9, 421-425
 |  Abstract »  |  Full Text »

Carotenoids and carotenoids plus vitamin E protect against ultraviolet light-induced erythema in humans.

W. Stahl, U. Heinrich, H. Jungmann, H. Sies, and H. Tronnier (2000)
Am. J. Clinical Nutrition 71, 795-798
 |  Abstract »  |  Full Text »  |  PDF »

The Canary in the Cell: A Sentinel Role for {beta}-Carotene.

R. J. Jandacek (2000)
J. Nutr. 130, 648-651
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Oxidative DNA damage in human lymphocytes: correlations with plasma levels of {alpha}-tocopherol and carotenoids.

F. Bianchini, S. Elmstahl, C. Martinez-Garcia, A.-L. van Kappel, T. Douki, J. Cadet, H. Ohshima, E. Riboli, and R. Kaaks (2000)
Carcinogenesis 21, 321-324
 |  Abstract »  |  Full Text »  |  PDF »

Oxidative DNA Damage by Vitamin A and Its Derivative via Superoxide Generation.

M. Murata and S. Kawanishi (2000)
J. Biol. Chem. 275, 2003-2008
 |  Abstract »  |  Full Text »  |  PDF »

{beta}-Carotene Supplementation and Incidence of Cancer and Cardiovascular Disease: the Women's Health Study.

I.-M. Lee, N. R. Cook, J. E. Manson, J. E. Buring, and C. H. Hennekens (1999)
J Natl Cancer Inst 91, 2102-2106
 |  Abstract »  |  Full Text »  |  PDF »

Enhanced Formation of alpha -Tocopherol and Highly Oxidized Abietane Diterpenes in Water-Stressed Rosemary Plants.

S. Munné-Bosch, K. Schwarz, and L. Alegre (1999)
Plant Physiology 121, 1047-1052
 |  Abstract »  |  Full Text »

Prevention of Cancer in the Next Millennium: Report of the Chemoprevention Working Group to the American Association for Cancer Research.

(1999)
Cancer Res. 59, 4743-4758
 |  Full Text »  |  PDF »

{beta}-Carotene and Other Carotenoids as Antioxidants.

S. A.R. Paiva and R. M. Russell (1999)
J. Am. Coll. Nutr. 18, 426-433
 |  Abstract »  |  Full Text »  |  PDF »

Long-term {beta}-Carotene Supplementation and Risk of Type 2 Diabetes Mellitus: A Randomized Controlled Trial.

S. Liu, U. Ajani, C. Chae, C. Hennekens, J. E. Buring, and J. E. Manson (1999)
JAMA 282, 1073-1075
 |  Abstract »  |  Full Text »  |  PDF »

Anhydroretinol Induces Oxidative Stress and Cell Death.

Y. Chen, J. Buck, and F. Derguini (1999)
Cancer Res. 59, 3985-3990
 |  Abstract »  |  Full Text »  |  PDF »

Alcohol, vitamin A, and {beta}-carotene: adverse interactions, including hepatotoxicity and carcinogenicity.

M. A Leo and C. S Lieber (1999)
Am. J. Clinical Nutrition 69, 1071-1085
 |  Abstract »  |  Full Text »  |  PDF »

Dietary ß-Carotene and {alpha}-Tocopherol Combination Does Not Inhibit Atherogenesis in an ApoE–Deficient Mouse Model.

A. Shaish, J. George, B. Gilburd, P. Keren, H. Levkovitz, and D. Harats (1999)
Arterioscler Thromb Vasc Biol 19, 1470-1475
 |  Abstract »  |  Full Text »  |  PDF »

Double blind, cluster randomised trial of low dose supplementation with vitamin A or beta  carotene on mortality related to pregnancy in Nepal.

K. P West Jr, J. Katz, S. K Khatry, S. C LeClerq, E. K Pradhan, S. R Shrestha, P. B Connor, S. M Dali, P. Christian, R. P Pokhrel, et al. (1999)
BMJ 318, 570-575
 |  Abstract »  |  Full Text »

Supplementation with Canthaxanthin Affects Plasma and Tissue Distribution of alpha - and gamma -Tocopherols in Mice.

P. Palozza, G. Calviello, S. Serini, P. Moscato, and G. M. Bartoli (1998)
J. Nutr. 128, 1989-1994
 |  Abstract »  |  Full Text »

Relationship of Plasma Carotenoids, Retinol and Tocopherols in Mothers and Newborn Infants.

K.-J. Yeum, G. Ferland, J. Patry, and R. M. Russell (1998)
J. Am. Coll. Nutr. 17, 442-447
 |  Abstract »  |  Full Text »  |  PDF »

Effect of Thyroid Function on LDL Oxidation.

F. Costantini, S. D. Pierdomenico, D. D. Cesare, P. De Remigis, T. Bucciarelli, G. Bittolo-Bon, G. Cazzolato, G. Nubile, M. T. Guagnano, S. Sensi, et al. (1998)
Arterioscler Thromb Vasc Biol 18, 732-737
 |  Abstract »  |  Full Text »  |  PDF »

Oxidative Changes Associated with {beta}-Carotene and {alpha}-Tocopherol Enrichment of Human Low-Density Lipoproteins.

H. T. Bowen and S. T. Omaye (1998)
J. Am. Coll. Nutr. 17, 171-179
 |  Abstract »  |  Full Text »  |  PDF »

The Effect of Alpha-Tocopherol and Beta-Carotene Supplementation on COPD Symptoms.

M. RAUTALAHTI, J. VIRTAMO, J. HAUKKA, O. P. HEINONEN, J. SUNDVALL, D. ALBANES, and J. K. HUTTUNEN (1997)
Am. J. Respir. Crit. Care Med. 156, 1447-1452
 |  Abstract »  |  Full Text »

Probucol and Multivitamins in the Prevention of Restenosis after Coronary Angioplasty.

J.-C. Tardif, G. Cote, J. Lesperance, M. Bourassa, J. Lambert, S. Doucet, L. Bilodeau, S. Nattel, P. de Guise, and The Multivitamins and Probucol Study Group (1997)
N. Engl. J. Med. 337, 365-372
 |  Abstract »  |  Full Text »  |  PDF »

Dietary Antioxidants and Parkinson Disease: The Rotterdam Study.

M. C. de Rijk, M. M. B. Breteler, J. H. den Breeijen, L. J. Launer, D. E. Grobbee, F. G. A. van der Meche, and A. Hofman (1997)
Arch Neurol 54, 762-765
 |  Abstract »  |  PDF »

Topical Review: Antidyskinetic Drug Therapy for Pediatric Movement Disorders.

M. R. Pranzatelli (1996)
J Child Neurol 11, 355-369
 |  Abstract »  |  PDF »

Lack of Effect of Long-Term Supplementation with Beta Carotene on the Incidence of Malignant Neoplasms and Cardiovascular Disease.

C. H. Hennekens, J. E. Buring, J. E. Manson, M. Stampfer, B. Rosner, N. R. Cook, C. Belanger, F. LaMotte, J. M. Gaziano, P. M. Ridker, et al. (1996)
N. Engl. J. Med. 334, 1145-1149
 |  Abstract »  |  Full Text »  |  PDF »

Effects of a Combination of Beta Carotene and Vitamin A on Lung Cancer and Cardiovascular Disease.

G. S. Omenn, G. E. Goodman, M. D. Thornquist, J. Balmes, M. R. Cullen, A. Glass, J. P. Keogh, F. L. Meyskens, B. Valanis, J. H. Williams, et al. (1996)
N. Engl. J. Med. 334, 1150-1155
 |  Abstract »  |  Full Text »  |  PDF »

Scavenging of Nitrogen Dioxide, Thiyl, and Sulfonyl Free Radicals by the Nutritional Antioxidant beta-Carotene.

S. A. Everett, M. F. Dennis, K. B. Patel, S. Maddix, S. C. Kundu, and R. L. Willson (1996)
J. Biol. Chem. 271, 3988-3994
 |  Abstract »  |  Full Text »  |  PDF »

Singlet Oxygen and Peroxyl Radicals Regulate Carotenoid Biosynthesis in Phaffia rhodozyma.

W. A. Schroeder and E. A. Johnson (1995)
J. Biol. Chem. 270, 18374-18379
 |  Abstract »  |  Full Text »  |  PDF »

Suppressive Effect of {beta}-Carotene on the Development of Pulmonary Foam Cells in Rats with Hyper {beta}-Lipoproteinemia.

K. Shibuya, M. Tajima, T. Saitoh, J. Yamate, and T. Nunoya (1995)
Toxicol Pathol 23, 47-55
 |  Abstract »  |  PDF »

Nutrition Support in Bone Marrow Transplant Recipients.

V. M. Herrmann and P. J. Petruska (1993)
Nutr Clin Pract 8, 19-27
 |  Abstract »  |  PDF »

Hypocarotenemia in Patients Fed Enterally with Commercial Liquid Diets.

P. E. Bowen, S. Mobarhan, C. Henderson, M. Stacewicz-Sapuntzakis, H. Friedman, and R. Kaiser (1988)
JPEN J Parenter Enteral Nutr 12, 484-489
 |  Abstract »  |  PDF »

Antioxidant Status in Persons With and Without Senile Cataract.

P. F. Jacques, L. T. Chylack Jr, R. B. McGandy, and S. C. Hartz (1988)
Arch Ophthalmol 106, 337-340
 |  Abstract »  |  PDF »

Bilirubin is an antioxidant of possible physiological importance.

R Stocker, Y Yamamoto, A. McDonagh, A. Glazer, and B. Ames (1987)
Science 235, 1043-1046
 |  Abstract »  |  PDF »

Diet and Lung Cancer: A Review of the Epidemiologic Evidence in Humans.

G. A. Colditz, M. J. Stampfer, and W. C. Willett (1987)
Arch Intern Med 147, 157-160
 |  Abstract »  |  PDF »

Multiple-Organ-Failure Syndrome.

C. J. Carrico, J. L. Meakins, J. C. Marshall, D. Fry, and R. V. Maier (1986)
Arch Surg 121, 196-208
 |  Abstract »  |  PDF »

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