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Science 4 May 1984:
Vol. 224. no. 4648, pp. 519 - 521
DOI: 10.1126/science.6324348
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Articles

Science, Vol 224, Issue 4648, 519-521
Copyright © 1984 by American Association for the Advancement of Science

articles

Behavioral sensitivity to purinergic drugs parallels ethanol sensitivity in selectively bred mice

WR Proctor and TV Dunwiddie

Behavioral responses to an adenosine receptor agonist and antagonist were examined in mice genetically selected for differential sensitivity to the soporific effects of ethanol. Both ethanol and the adenosine receptor agonist L-phenylisopropyladenosine had greater sedative and hypothermic effects in ethanol-sensitive "long-sleep" mice than in ethanol-insensitive "short-sleep" mice. Long-sleep mice were also more sensitive to the excitatory behavioral effects of theophylline, an adenosine receptor antagonist. These data suggest that adenosine may be an endogenous mediator of responses to ethanol.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)