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Science 4 May 1984:
Vol. 224. no. 4648, pp. 509 - 511
DOI: 10.1126/science.6324346
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Articles

Science, Vol 224, Issue 4648, 509-511
Copyright © 1984 by American Association for the Advancement of Science

articles

Inhibition of platelet aggregation by monoclonal antibody reactive with beta 2-microglobulin chain of HLA complex

RA Curry, RP Messner, and GJ Johnson

A mouse monoclonal antibody that reacts with beta 2-microglobulin, the light chain of class I major histocompatibility antigens, inhibited the second wave of human platelet aggregation induced by adenosine diphosphate and epinephrine and blocked aggregation and platelet protein phosphorylation induced by sodium arachidonate. Thrombin-induced platelet aggregation was inhibited at threshold concentrations but not at higher concentrations. The antibody also inhibited aggregation and secretion in response to thromboxane A2 or the stable endoperoxide analog, U46619. These results suggest that beta 2-microglobulin in the histocompatibility complex is intimately associated with transmission of the endoperoxide-thromboxane signal at the platelet membrane.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Role for beta 2-Microglobulin in Echovirus Infection of Rhabdomyosarcoma Cells.
T. Ward, R. M. Powell, P. A. Pipkin, D. J. Evans, P. D. Minor, and J. W. Almond (1998)
J. Virol. 72, 5360-5365
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