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Science 4 May 1984:
Vol. 224. no. 4648, pp. 506 - 508
DOI: 10.1126/science.6324345
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Articles

Science, Vol 224, Issue 4648, 506-508
Copyright © 1984 by American Association for the Advancement of Science

articles

Antibodies reactive with human T-lymphotropic retroviruses (HTLV-III) in the serum of patients with AIDS

MG Sarngadharan, M Popovic, L Bruch, J Schupbach, and RC Gallo

In cats, infection with T-lymphotropic retroviruses can cause T-cell proliferation and leukemia or T-cell depletion and immunosuppression. In humans, some highly T4 tropic retroviruses called HTLV-I can cause T-cell proliferation and leukemia. The subgroup HTLV-II also induces T-cell proliferation in vitro, but its role in disease is unclear. Viruses of a third subgroup of human T-lymphotropic retroviruses, collectively designated HTLV-III, have been isolated from cultured cells of 48 patients with acquired immunodeficiency syndrome (AIDS). The biological properties of HTLV-III and immunological analyses of its proteins show that this virus is a member of the HTLV family, and that it is more closely related to HTLV-II than to HTLV-I. Serum samples from 88 percent of patients with AIDS and from 79 percent of homosexual men with signs and symptoms that frequently precede AIDS, but from less than 1 percent of heterosexual subjects, have antibodies reactive against antigens of HTLV-III. The major immune reactivity appears to be directed against p41, the presumed envelope antigen of the virus.


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JAMA 255, 212-215
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JAMA 254, 2599-2602
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Ann Intern Med 103, 679-689
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Ann Intern Med 103, 710-714
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Ann Intern Med 103, 744-750
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Inhibition of lymphocyte proliferation by a synthetic peptide homologous to retroviral envelope proteins.
G. Cianciolo, T. Copeland, S Oroszlan, and R Snyderman (1985)
Science 230, 453-455
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HTLV-III Infection Among Health Care Workers: Association With Needle-Stick Injuries.
S. H. Weiss, W. C. Saxinger, D. Rechtman, M. H. Grieco, J. Nadler, S. Holman, H. M. Ginzburg, J. E. Groopman, J. J. Goedert, P. D. Markham, et al. (1985)
JAMA 254, 2089-2093
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Retrovirus and Malignant Lymphoma in Homosexual Men.
A. M. Levine, P. S. Gill, P. R. Meyer, R. L. Burkes, R. Ross, R. D. Dworsky, M. Krailo, J. W. Parker, R. J. Lukes, and S. Rasheed (1985)
JAMA 254, 1921-1925
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Characterization of gp41 as the transmembrane protein coded by the HTLV-III/LAV envelope gene.
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Science 229, 1402-1405
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Science 229, 563-566
   Abstract »    PDF »
Trans-activator gene of human T-lymphotropic virus type III (HTLV-III).
S. Arya, C Guo, S. Josephs, and F Wong-Staal (1985)
Science 229, 69-73
   Abstract »    PDF »
Location of the trans-activating region on the genome of human T-cell lymphotropic virus type III.
J Sodroski, R Patarca, C Rosen, F Wong-Staal, and W Haseltine (1985)
Science 229, 74-77
   Abstract »    PDF »
AIDS Serology Testing in Low- and High-Risk Groups.
J. R. Carlson, M. L. Bryant, S. H. Hinrichs, J. K. Yamamoto, N. B. Levy, J. Yee, J. Higgins, A. M. Levine, P. Holland, M. B. Gardner, et al. (1985)
JAMA 253, 3405-3408
   Abstract »    PDF »
Human T-Lymphotropic Retrovirus Type III / Lymphadenopathy-Associated Virus Antibody: Association With Hemophiliacs' Immune Status and Blood Component Usage.
J. Jason, J. S. McDougal, R. C. Holman, S. F. Stein, D. N. Lawrence, J. K. A. Nicholson, G. Dixon, M. Doxey, B. L. Evatt, and the Hemophilia/AIDS Collaborative Study Group (1985)
JAMA 253, 3409-3415
   Abstract »    PDF »
Potential Liability for Transfusion-Associated AIDS.
P. J. Miller, J. O'Connell, A. Leipold, and R. P. Wenzel (1985)
JAMA 253, 3419-3424
   Abstract »    PDF »
A transcriptional activator protein encoded by the x-lor region of the human T-cell leukemia virus.
J Sodroski, C Rosen, W. Goh, and W Haseltine (1985)
Science 228, 1430-1434
   Abstract »    PDF »
Serologic identification and characterization of a macaque T-lymphotropic retrovirus closely related to HTLV-III.
P. Kanki, M. McLane, N. King Jr, N. Letvin, R. Hunt, P Sehgal, M. Daniel, R. Desrosiers, and M Essex (1985)
Science 228, 1199-1201
   Abstract »    PDF »
Isolation of T-cell tropic HTLV-III-like retrovirus from macaques.
M. Daniel, N. Letvin, N. King, M Kannagi, P. Sehgal, R. Hunt, P. Kanki, M Essex, and R. Desrosiers (1985)
Science 228, 1201-1204
   Abstract »    PDF »
Naturally occurring antibodies reactive with sperm proteins: apparent deficiency in AIDS sera.
T. Rodman, J Laurence, F. Pruslin, N Chiorazzi, and R Winston (1985)
Science 228, 1211-1215
   Abstract »    PDF »
Reactivation of Chronic Type B Hepatitis Presenting as Acute Viral Hepatitis.
G. L. DAVIS and J. H. HOOFNAGLE (1985)
Ann Intern Med 102, 762-765
   Abstract »    PDF »


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