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Science 4 May 1984:
Vol. 224. no. 4648, pp. 497 - 500
DOI: 10.1126/science.6200935
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Articles

Science, Vol 224, Issue 4648, 497-500
Copyright © 1984 by American Association for the Advancement of Science

articles

Detection, isolation, and continuous production of cytopathic retroviruses (HTLV-III) from patients with AIDS and pre-AIDS

M Popovic, MG Sarngadharan, E Read, and RC Gallo

A cell system was developed for the reproducible detection of human T-lymphotropic retroviruses (HTLV family) from patients with the acquired immunodeficiency syndrome (AIDS) or with signs or symptoms that frequently precede AIDS (pre-AIDS). The cells are specific clones from a permissive human neoplastic T-cell line. Some of the clones permanently grow and continuously produce large amounts of virus after infection with cytopathic (HTLV-III) variants of these viruses. One cytopathic effect of HTLV-III in this system is the arrangement of multiple nuclei in a characteristic ring formation in giant cells of the infected T-cell population. These structures can be used as an indicator to detect HTLV-III in clinical specimens. This system opens the way to the routine detection of HTLV-III and related cytopathic variants of HTLV in patients with AIDS or pre-AIDS and in healthy carriers, and it provides large amounts of virus for detailed molecular and immunological analyses.


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J. Virol. 76, 11033-11041
   Abstract »    Full Text »    PDF »
Characterization of a human immunodeficiency virus type 1 pre-integration complex in which the majority of the cDNA is resistant to DNase I digestion.
D. K. Khiytani and N. J. Dimmock (2002)
J. Gen. Virol. 83, 2523-2532
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Antiretrovirus Activity of a Novel Class of Acyclic Pyrimidine Nucleoside Phosphonates.
J. Balzarini, C. Pannecouque, E. De Clercq, S. Aquaro, C.-F. Perno, H. Egberink, and A. Holy (2002)
Antimicrob. Agents Chemother. 46, 2185-2193
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A Tight-Binding Mode of Inhibition Is Essential for Anti-Human Immunodeficiency Virus Type 1 Virucidal Activity of Nonnucleoside Reverse Transcriptase Inhibitors.
D. Motakis and M. A. Parniak (2002)
Antimicrob. Agents Chemother. 46, 1851-1856
   Abstract »    Full Text »    PDF »
Cytopathic Killing of Peripheral Blood CD4+ T Lymphocytes by Human Immunodeficiency Virus Type 1 Appears Necrotic rather than Apoptotic and Does Not Require env.
M. J. Lenardo, S. B. Angleman, V. Bounkeua, J. Dimas, M. G. Duvall, M. B. Graubard, F. Hornung, M. C. Selkirk, C. K. Speirs, C. Trageser, et al. (2002)
J. Virol. 76, 5082-5093
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C. Speth, T. Schabetsberger, I. Mohsenipour, G. Stockl, R. Wurzner, H. Stoiber, C. Lass-Florl, and M. P. Dierich (2002)
J. Virol. 76, 3179-3188
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Nef-Mediated Resistance of Human Immunodeficiency Virus Type 1 to Antiviral Cytotoxic T Lymphocytes.
O. O. Yang, P. T. Nguyen, S. A. Kalams, T. Dorfman, H. G. Gottlinger, S. Stewart, I. S. Y. Chen, S. Threlkeld, and B. D. Walker (2002)
J. Virol. 76, 1626-1631
   Abstract »    Full Text »    PDF »
Oxidative Modifications of Kynostatin-272, a Potent Human Immunodeficiency Virus Type 1 Protease Inhibitor: Potential Mechanism for Altered Activity in Monocytes/Macrophages.
D. A. Davis, E. Read-Connole, K. Pearson, H. M. Fales, F. M. Newcomb, J. Moskovitz, and R. Yarchoan (2002)
Antimicrob. Agents Chemother. 46, 402-408
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Induction of Rapid and Extensive beta -Chemokine Synthesis in Macrophages by Human Immunodeficiency Virus Type 1 and gp120, Independently of Their Coreceptor Phenotype.
W. Choe, D. J. Volsky, and M. J. Potash (2001)
J. Virol. 75, 10738-10745
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Human Immunodeficiency Virus Type 1 IIIB Selected for Replication In Vivo Exhibits Increased Envelope Glycoproteins in Virions without Alteration in Coreceptor Usage: Separation of In Vivo Replication from Macrophage Tropism.
E. D. Miller, K. M. Duus, M. Townsend, Y. Yi, R. Collman, M. Reitz, and L. Su (2001)
J. Virol. 75, 8498-8506
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Human Immunodeficiency Virus Type 1 Replication in the Absence of Integrase-Mediated DNA Recombination: Definition of Permissive and Nonpermissive T-Cell Lines.
N. Nakajima, R. Lu, and A. Engelman (2001)
J. Virol. 75, 7944-7955
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Separation of Human Immunodeficiency Virus Type 1 Replication from nef-Mediated Pathogenesis in the Human Thymus.
K. M. Duus, E. D. Miller, J. A. Smith, G. I. Kovalev, and L. Su (2001)
J. Virol. 75, 3916-3924
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Human Immunodeficiency Virus Type 1 Induces Expression of Complement Factors in Human Astrocytes.
C. Speth, G. Stöckl, I. Mohsenipour, R. Würzner, H. Stoiber, C. Lass-Flörl, and M. P. Dierich (2001)
J. Virol. 75, 2604-2615
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Role for Human Immunodeficiency Virus Type 1 Tat Protein in Suppression of Viral Reverse Transcriptase Activity during Late Stages of Viral Replication.
M. Kameoka, L. Rong, M. Götte, C. Liang, R. S. Russell, and M. A. Wainberg (2001)
J. Virol. 75, 2675-2683
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GLI-2 Modulates Retroviral Gene Expression.
M. J. Smith, S. D. Gitlin, C. M. Browning, B. R. Lane, N. M. Clark, N. Shah, S. Rainier, and D. M. Markovitz (2001)
J. Virol. 75, 2301-2313
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Partial Activation and Induction of Apoptosis in CD4+ and CD8+ T Lymphocytes by Conformationally Authentic Noninfectious Human Immunodeficiency Virus Type 1.
M. T. Esser, J. W. Bess Jr., K. Suryanarayana, E. Chertova, D. Marti, M. Carrington, L. O. Arthur, and J. D. Lifson (2001)
J. Virol. 75, 1152-1164
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Polyanionic (i.e., Polysulfonate) Dendrimers Can Inhibit the Replication of Human Immunodeficiency Virus by Interfering with Both Virus Adsorption and Later Steps (Reverse Transcriptase/Integrase) in the Virus Replicative Cycle.
M. Witvrouw, V. Fikkert, W. Pluymers, B. Matthews, K. Mardel, D. Schols, J. Raff, Z. Debyser, E. De Clercq, G. Holan, et al. (2000)
Mol. Pharmacol. 58, 1100-1108
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Intercellular delivery of a herpes simplex virus VP22 fusion protein from cells infected with lentiviral vectors.
Z. Lai, I. Han, G. Zirzow, R. O. Brady, and J. Reiser (2000)
PNAS 97, 11297-11302
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Primary macrophages infected by human immunodeficiency virus trigger CD95-mediated apoptosis of uninfected astrocytes.
S. Aquaro, S. Panti, M. C. Caroleo, E. Balestra, A. Cenci, F. Forbici, G. Ippolito, A. Mastino, R. Testi, V. Mollace, et al. (2000)
J. Leukoc. Biol. 68, 429-435
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Viral Entry as the Primary Target for the Anti-HIV Activity of Chicoric Acid and Its Tetra-Acetyl Esters.
W. Pluymers, N. Neamati, C. Pannecouque, V. Fikkert, C. Marchand, T. R. Burke Jr., Y. Pommier, D. Schols, E. De Clercq, Z. Debyser, et al. (2000)
Mol. Pharmacol. 58, 641-648
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Performance of a Multiplex Qualitative PCR LCx Assay for Detection of Human Immunodeficiency Virus Type 1 (HIV-1) Group M Subtypes, Group O, and HIV-2.
K. Abravaya, C. Esping, R. Hoenle, J. Gorzowski, R. Perry, P. Kroeger, J. Robinson, and R. Flanders (2000)
J. Clin. Microbiol. 38, 716-723
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PCR-derived ssDNA Probes for Fluorescent In Situ Hybridization to HIV-1 RNA.
M. C. Knuchel, B. Graf, E. Schlaepfer, H. Kuster, M. Fischer, R. Weber, and R. W. Cone (2000)
J. Histochem. Cytochem. 48, 285-294
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Reversal of Human Immunodeficiency Virus Type 1 Protein-Induced Inhibition of Natural Killer Cell Activity by Alpha Interferon and Interleukin-2.
M. P. N. Nair and S. A. Schwartz (2000)
Clin. Vaccine Immunol. 7, 101-105
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A Second Target for the Peptoid Tat/Transactivation Response Element Inhibitor CGP64222: Inhibition of Human Immunodeficiency Virus Replication by Blocking CXC-Chemokine Receptor 4-Mediated Virus Entry.
D. Daelemans, D. Schols, M. Witvrouw, C. Pannecouque, S. Hatse, S. van Dooren, F. Hamy, T. Klimkait, E. de Clercq, and A.-M. VanDamme (2000)
Mol. Pharmacol. 57, 116-124
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Determinants of CD4 Independence for a Human Immunodeficiency Virus Type 1 Variant Map outside Regions Required for Coreceptor Specificity.
C. C. LaBranche, T. L. Hoffman, J. Romano, B. S. Haggarty, T. G. Edwards, T. J. Matthews, R. W. Doms, and J. A. Hoxie (1999)
J. Virol. 73, 10310-10319
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Pseudotyping human immunodeficiency virus type 1 by vesicular stomatitis virus G protein does not reduce the cell-dependent requirement of Vif for optimal infectivity: functional difference between Vif and Nef.
H. Akari, T. Uchiyama, T. Fukumori, S. Iida, A. H. Koyama, and A. Adachi (1999)
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   Abstract »    Full Text »    PDF »
Multiplex detection of four pathogenic retroviruses using molecular beacons.
J. A. M. Vet, A. R. Majithia, S. A. E. Marras, S. Tyagi, S. Dube, B. J. Poiesz, and F. R. Kramer (1999)
PNAS 96, 6394-6399
   Abstract »    Full Text »    PDF »
Evaluation of a Rapid Immunochromatographic Test for Detection of Antibodies to Human Immunodeficiency Virus.
H. Arai, B. Petchclai, K. Khupulsup, T. Kurimura, and K. Takeda (1999)
J. Clin. Microbiol. 37, 367-370
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CD4+ T-Lymphocyte Depletion in Human Lymphoid Tissue Ex Vivo Is Not Induced by Noninfectious Human Immunodeficiency Virus Type 1 Virions.
A. W. Sylwester, J.-C. Grivel, W. Fitzgerald, J. L. Rossio, J. D. Lifson, and L. B. Margolis (1998)
J. Virol. 72, 9345-9347
   Abstract »    Full Text »    PDF »
Selective Inhibition of HIV-1 Reverse Transcriptase by an Antiviral Inhibitor, (R)-9-(2-Phosphonylmethoxypropyl)adenine.
Z. Suo and K. A. Johnson (1998)
J. Biol. Chem. 273, 27250-27258
   Abstract »    Full Text »    PDF »
Chronically HIV-1-Infected Monocytic Cells Induce Apoptosis in Cocultured T Cells.
H. Chen, Y. K. Yip, I. George, M. Tyorkin, E. Salik, and K. Sperber (1998)
J. Immunol. 161, 4257-4267
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Common Themes of Antibody Maturation to Simian Immunodeficiency Virus, Simian-Human Immunodeficiency Virus, and Human Immunodeficiency Virus Type 1 Infections.
K. S. Cole, M. Murphey-Corb, O. Narayan, S. V. Joag, G. M. Shaw, and R. C. Montelaro (1998)
J. Virol. 72, 7852-7859
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Dissociation of the CD4 and CXCR4 Binding Properties of Human Immunodeficiency Virus Type 1 gp120 by Deletion of the First Putative Alpha-Helical Conserved Structure.
D. Misse, M. Cerutti, I. Schmidt, A. Jansen, G. Devauchelle, F. Jansen, and F. Veas (1998)
J. Virol. 72, 7280-7288
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Continued Utilization of CCR5 Coreceptor by a Newly Derived T-Cell Line-Adapted Isolate of Human Immunodeficiency Virus Type 1.
K. E. Follis, M. Trahey, R. A. LaCasse, and J. H. Nunberg (1998)
J. Virol. 72, 7603-7608
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The leukotriene B4 receptor functions as a novel type of coreceptor mediating entry of primary HIV-1 isolates into CD4-positive cells.
C. Owman, A. Garzino-Demo, F. Cocchi, M. Popovic, A. Sabirsh, and R. C. Gallo (1998)
PNAS 95, 9530-9534
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Determinants of Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Activation by Soluble CD4 and Monoclonal Antibodies.
N. Sullivan, Y. Sun, J. Binley, J. Lee, C. F. Barbas III, P. W. H. I. Parren, D. R. Burton, and J. Sodroski (1998)
J. Virol. 72, 6332-6338
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Human Immunodeficiency Virus Type 1 Replication Is Modulated by Host Cyclophilin A Expression Levels.
L. Yin, D. Braaten, and J. Luban (1998)
J. Virol. 72, 6430-6436
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CD4-Induced Conformational Changes in the Human Immunodeficiency Virus Type 1 gp120 Glycoprotein: Consequences for Virus Entry and Neutralization.
N. Sullivan, Y. Sun, Q. Sattentau, M. Thali, D. Wu, G. Denisova, J. Gershoni, J. Robinson, J. Moore, and J. Sodroski (1998)
J. Virol. 72, 4694-4703
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Novel Inhibitory Effects of gamma -Glutamylcysteine Ethyl Ester against Human Immunodeficiency Virus Type 1 Production and Propagation.
S. Kubota, S. Shetty, H. Zhang, S. Kitahara, and R. J. Pomerantz (1998)
Antimicrob. Agents Chemother. 42, 1200-1206
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Characterization of V3 Loop-Pseudomonas Exotoxin Chimeras. CANDIDATE VACCINES FOR HUMAN IMMUNODEFICIENCY VIRUS-1.
D. J. FitzGerald, C. M. Fryling, M. L. McKee, J. C. Vennari, T. Wrin, M. E. M. Cromwell, A. L. Daugherty, and R. J. Mrsny (1998)
J. Biol. Chem. 273, 9951-9958
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Cleavage of Human Immunodeficiency Virus Type 1 Proteinase from the N-Terminally Adjacent p6* Protein Is Essential for Efficient Gag Polyprotein Processing and Viral Infectivity.
U. Tessmer and H.-G. Krausslich (1998)
J. Virol. 72, 3459-3463
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The Lipophosphoglycan of Leishmania donovani Up-Regulates HIV-1 Transcription in T Cells Through the Nuclear Factor-{kappa}B Elements.
R. Bernier, B. Barbeau, M. J. Tremblay, and M. Olivier (1998)
J. Immunol. 160, 2881-2888
   Abstract »    Full Text »    PDF »
1,1,3-Trioxo-2H,4H-Thieno[3,4-e][1,2,4]Thiadiazine (TTD) Derivatives: a New Class of Nonnucleoside Human Immunodeficiency Virus Type 1 (HIV-1) Reverse Transcriptase Inhibitors with Anti-HIV-1 Activity.
M. Witvrouw, M. E. Arranz, C. Pannecouque, R. Declercq, H. Jonckheere, J.-C. Schmit, A.-M. Vandamme, J. A. Diaz, S. T. Ingate, J. Desmyter, et al. (1998)
Antimicrob. Agents Chemother. 42, 618-623
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Nucleocapsid and Matrix Protein Contributions to Selective Human Immunodeficiency Virus Type 1 Genomic RNA Packaging.
D. T. K. Poon, G. Li, and A. Aldovini (1998)
J. Virol. 72, 1983-1993
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Evolution of a Simian Immunodeficiency Virus Pathogen.
P. Edmonson, M. Murphey-Corb, L. N. Martin, C. Delahunty, J. Heeney, H. Kornfeld, P. R. Donahue, G. H. Learn, L. Hood, and J. I. Mullins (1998)
J. Virol. 72, 405-414
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Spontaneous Mutations in the env Gene of the Human Immunodeficiency Virus Type 1 NDK Isolate Are Associated with a CD4-Independent Entry Phenotype.
J. Dumonceaux, S. Nisole, C. Chanel, L. Quivet, A. Amara, P. Briand, and U. Hazan (1998)
J. Virol. 72, 512-519
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Mutations in HIV reverse transcriptase which alter RNase H activity and decrease strand transfer efficiency are suppressed by HIV nucleocapsid protein.
C. E. Cameron, M. Ghosh, S. F. J. Le Grice, and S. J. Benkovic (1997)
PNAS 94, 6700-6705
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The Human Immunodeficiency Virus Type 1 (HIV-1) Vpu Protein Interferes with an Early Step in the Biosynthesis of Major Histocompatibility Complex (MHC) Class I Molecules.
T. Kerkau, I. Bacik, J. R. Bennink, J. W. Yewdell, T. Hunig, A. Schimpl, and U. Schubert (1997)
J. Exp. Med. 185, 1295-1306
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Increased Uptake and Accumulation of Vitamin C in Human Immunodeficiency Virus 1-infected Hematopoietic Cell Lines.
C. I. Rivas, J. C. Vera, V. H. Guaiquil, F. V. Velasquez, O. A. Borquez-Ojeda, J. G. Carcamo, I. I. Concha, and D. W. Golde (1997)
J. Biol. Chem. 272, 5814-5820
   Abstract »    Full Text »    PDF »


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