Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 4 May 1984:
Vol. 224. no. 4648, pp. 497 - 500
DOI: 10.1126/science.6200935
Prev | Table of Contents | Next

Articles

Science, Vol 224, Issue 4648, 497-500
Copyright © 1984 by American Association for the Advancement of Science

articles

Detection, isolation, and continuous production of cytopathic retroviruses (HTLV-III) from patients with AIDS and pre-AIDS

M Popovic, MG Sarngadharan, E Read, and RC Gallo

A cell system was developed for the reproducible detection of human T-lymphotropic retroviruses (HTLV family) from patients with the acquired immunodeficiency syndrome (AIDS) or with signs or symptoms that frequently precede AIDS (pre-AIDS). The cells are specific clones from a permissive human neoplastic T-cell line. Some of the clones permanently grow and continuously produce large amounts of virus after infection with cytopathic (HTLV-III) variants of these viruses. One cytopathic effect of HTLV-III in this system is the arrangement of multiple nuclei in a characteristic ring formation in giant cells of the infected T-cell population. These structures can be used as an indicator to detect HTLV-III in clinical specimens. This system opens the way to the routine detection of HTLV-III and related cytopathic variants of HTLV in patients with AIDS or pre-AIDS and in healthy carriers, and it provides large amounts of virus for detailed molecular and immunological analyses.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Plasmacytoid dendritic cells express TRAIL and induce CD4+ T-cell apoptosis in HIV-1 viremic patients.
G. Stary, I. Klein, S. Kohlhofer, F. Koszik, T. Scherzer, L. Mullauer, H. Quendler, N. Kohrgruber, and G. Stingl (2009)
Blood 114, 3854-3863
   Abstract »    Full Text »    PDF »
Transitions to and from the CD4-Bound Conformation Are Modulated by a Single-Residue Change in the Human Immunodeficiency Virus Type 1 gp120 Inner Domain.
A. Kassa, N. Madani, A. Schon, H. Haim, A. Finzi, S.-H. Xiang, L. Wang, A. Princiotto, M. Pancera, J. Courter, et al. (2009)
J. Virol. 83, 8364-8378
   Abstract »    Full Text »    PDF »
Human Immunodeficiency Virus Type 1 Elite Neutralizers: Individuals with Broad and Potent Neutralizing Activity Identified by Using a High-Throughput Neutralization Assay together with an Analytical Selection Algorithm.
M. D. Simek, W. Rida, F. H. Priddy, P. Pung, E. Carrow, D. S. Laufer, J. K. Lehrman, M. Boaz, T. Tarragona-Fiol, G. Miiro, et al. (2009)
J. Virol. 83, 7337-7348
   Abstract »    Full Text »    PDF »
Albumin-conjugated C34 Peptide HIV-1 Fusion Inhibitor: EQUIPOTENT TO C34 AND T-20 IN VITRO WITH SUSTAINED ACTIVITY IN SCID-HU THY/LIV MICE.
C. A. Stoddart, G. Nault, S. A. Galkina, K. Thibaudeau, P. Bakis, N. Bousquet-Gagnon, M. Robitaille, M. Bellomo, V. Paradis, P. Liscourt, et al. (2008)
J. Biol. Chem. 283, 34045-34052
   Abstract »    Full Text »    PDF »
Activity of the Small Modified Amino Acid {alpha}-Hydroxy Glycineamide on In Vitro and In Vivo Human Immunodeficiency Virus Type 1 Capsid Assembly and Infectivity.
S. Abdurahman, A. Vegvari, M. Youssefi, M. Levi, S. Hoglund, E. Andersson, P. Horal, B. Svennerholm, J. Balzarini, and A. Vahlne (2008)
Antimicrob. Agents Chemother. 52, 3737-3744
   Abstract »    Full Text »    PDF »
Preclinical Evaluation of 1H-Benzylindole Derivatives as Novel Human Immunodeficiency Virus Integrase Strand Transfer Inhibitors.
A. Hombrouck, B. Van Remoortel, M. Michiels, W. Noppe, F. Christ, A. Eneroth, B. L. Sahlberg, K. Benkestock, L. Vrang, N. G. Johansson, et al. (2008)
Antimicrob. Agents Chemother. 52, 2861-2869
   Abstract »    Full Text »    PDF »
Comparative Evaluation of Virus Transmission Inhibition by Dual-Acting Pyrimidinedione Microbicides Using the Microbicide Transmission and Sterilization Assay.
K. M. Watson, C. E. Buckheit, and R. W. Buckheit Jr. (2008)
Antimicrob. Agents Chemother. 52, 2787-2796
   Abstract »    Full Text »    PDF »
Mutations in Human Immunodeficiency Virus Type 1 Integrase Confer Resistance to the Naphthyridine L-870,810 and Cross-Resistance to the Clinical Trial Drug GS-9137.
A. Hombrouck, A. Voet, B. Van Remoortel, C. Desadeleer, M. De Maeyer, Z. Debyser, and M. Witvrouw (2008)
Antimicrob. Agents Chemother. 52, 2069-2078
   Abstract »    Full Text »    PDF »
Toward an AIDS Vaccine.
B. D. Walker and D. R. Burton (2008)
Science 320, 760-764
   Abstract »    Full Text »    PDF »
Identification of functional microRNAs released through asymmetrical processing of HIV-1 TAR element.
D. L. Ouellet, I. Plante, P. Landry, C. Barat, M.-E. Janelle, L. Flamand, M. J. Tremblay, and P. Provost (2008)
Nucleic Acids Res. 36, 2353-2365
   Abstract »    Full Text »    PDF »
Active {beta}-Catenin Signaling Is an Inhibitory Pathway for Human Immunodeficiency Virus Replication in Peripheral Blood Mononuclear Cells.
A. Kumar, A. Zloza, R. T. Moon, J. Watts, A. R. Tenorio, and L. Al-Harthi (2008)
J. Virol. 82, 2813-2820
   Abstract »    Full Text »    PDF »
Comparative Evaluation of the Inhibitory Activities of a Series of Pyrimidinedione Congeners That Inhibit Human Immunodeficiency Virus Types 1 and 2.
R. W. Buckheit Jr., T. L. Hartman, K. M. Watson, S.-G. Chung, and E.-H. Cho (2008)
Antimicrob. Agents Chemother. 52, 225-236
   Abstract »    Full Text »    PDF »
In Vitro Antiviral Activity and Cross-Resistance Profile of PL-100, a Novel Protease Inhibitor of Human Immunodeficiency Virus Type 1.
S. Dandache, G. Sevigny, J. Yelle, B. R. Stranix, N. Parkin, J. M. Schapiro, M. A. Wainberg, and J. J. Wu (2007)
Antimicrob. Agents Chemother. 51, 4036-4043
   Abstract »    Full Text »    PDF »
Human Immunodeficiency Virus Type 1 Subtype Distribution in the Worldwide Epidemic: Pathogenetic and Therapeutic Implications.
L. Buonaguro, M. L. Tornesello, and F. M. Buonaguro (2007)
J. Virol. 81, 10209-10219
   Full Text »    PDF »
Reconstruction of the Hepatitis C Virus Epidemic in the US Hemophilia Population, 1940-1990.
J. J. Goedert, B. E. Chen, L. Preiss, L. M. Aledort, P. S. Rosenberg, and for the Second Multicenter Hemophilia Cohort Study (2007)
Am. J. Epidemiol. 165, 1443-1453
   Abstract »    Full Text »    PDF »
Efficiency of Human Immunodeficiency Virus Type 1 Postentry Infection Processes: Evidence against Disproportionate Numbers of Defective Virions.
J. A. Thomas, D. E. Ott, and R. J. Gorelick (2007)
J. Virol. 81, 4367-4370
   Abstract »    Full Text »    PDF »
Characterization of a Replication-Competent, Integrase-Defective Human Immunodeficiency Virus (HIV)/Simian Virus 40 Chimera as a Powerful Tool for the Discovery and Validation of HIV Integrase Inhibitors.
D. Daelemans, R. Lu, E. De Clercq, and A. Engelman (2007)
J. Virol. 81, 4381-4385
   Abstract »    Full Text »    PDF »
Novel In Vivo Model for the Study of Human Immunodeficiency Virus Type 1 Transcription Inhibitors: Evaluation of New 6-Desfluoroquinolone Derivatives.
M. Stevens, M. Pollicita, C. Pannecouque, E. Verbeken, O. Tabarrini, V. Cecchetti, S. Aquaro, C. F. Perno, A. Fravolini, E. De Clercq, et al. (2007)
Antimicrob. Agents Chemother. 51, 1407-1413
   Abstract »    Full Text »    PDF »
Inhibition of Human Immunodeficiency Virus Envelope Glycoprotein- Mediated Single Cell Lysis by Low-Molecular-Weight Antagonists of Viral Entry.
N. Madani, A. M. Hubicki, A. L. Perdigoto, M. Springer, and J. Sodroski (2007)
J. Virol. 81, 532-538
   Abstract »    Full Text »    PDF »
Overexpression of the Lens Epithelium-Derived Growth Factor/p75 Integrase Binding Domain Inhibits Human Immunodeficiency Virus Replication.
J. De Rijck, L. Vandekerckhove, R. Gijsbers, A. Hombrouck, J. Hendrix, J. Vercammen, Y. Engelborghs, F. Christ, and Z. Debyser (2006)
J. Virol. 80, 11498-11509
   Abstract »    Full Text »    PDF »
HIV-1 coreceptor preference is distinct from target cell tropism: a dual-parameter nomenclature to define viral phenotypes.
M. M. Goodenow and R. G. Collman (2006)
J. Leukoc. Biol. 80, 965-972
   Abstract »    Full Text »    PDF »
Development of a human immunodeficiency virus vector-based, single-cycle assay for evaluation of anti-integrase compounds..
R. Bona, M. Andreotti, V. Buffa, P. Leone, C. M. Galluzzo, R. Amici, L. Palmisano, M. G. Mancini, Z. Michelini, R. Di Santo, et al. (2006)
Antimicrob. Agents Chemother. 50, 3407-3417
   Abstract »    Full Text »    PDF »
Comparison of Human Immunodeficiency Virus Type 1-Specific Inhibitory Activities in Saliva and Other Human Mucosal Fluids.
S. H. Kazmi, J. R. Naglik, S. P. Sweet, R. W. Evans, S. O'Shea, J. E. Banatvala, and S. J. Challacombe (2006)
Clin. Vaccine Immunol. 13, 1111-1118
   Abstract »    Full Text »    PDF »
In Vitro Microbicidal Activity of the Nonnucleoside Reverse Transcriptase Inhibitor (NNRTI) UC781 against NNRTI-Resistant Human Immunodeficiency Virus Type 1.
M. M. Hossain and M. A. Parniak (2006)
J. Virol. 80, 4440-4446
   Abstract »    Full Text »    PDF »
Replication-dependent fitness recovery of Human immunodeficiency virus 1 harbouring mutations of Asn17 of the nucleocapsid protein..
J. Tozser, S. Shulenin, M. R. Young, C. J. Briggs, and S. Oroszlan (2006)
J. Gen. Virol. 87, 961-965
   Abstract »    Full Text »    PDF »
Cashing in on Shame: How the Popular "Tradition vs. Modernity" Dualism Contributes to the "HIV/AIDS Crisis" in Africa.
H. Lauer (2006)
Review of Radical Political Economics 38, 90-138
   Abstract »    PDF »
The Synthetic Peptide Derived from the NH2-terminal Extracellular Region of an Orphan G Protein-coupled Receptor, GPR1, Preferentially Inhibits Infection of X4 HIV-1.
A. Jinno-Oue, N. Shimizu, Y. Soda, A. Tanaka, T. Ohtsuki, D. Kurosaki, Y. Suzuki, and H. Hoshino (2005)
J. Biol. Chem. 280, 30924-30934
   Abstract »    Full Text »    PDF »
An Exonic Splicing Silencer Downstream of the 3' Splice Site A2 Is Required for Efficient Human Immunodeficiency Virus Type 1 Replication.
J. M. Madsen and C. M. Stoltzfus (2005)
J. Virol. 79, 10478-10486
   Abstract »    Full Text »    PDF »
What Caused the Epidemic of Pneumocystis Pneumonia in European Premature Infants in the Mid-20th Century?.
A. S. Goldman, L. R. Goldman, and D. A. Goldman (2005)
Pediatrics 115, e725-e736
   Abstract »    Full Text »    PDF »
Ex Vivo Modeling of Oral HIV Transmission in Human Palatine Tonsil.
D. M. Maher, Z.-Q. Zhang, T. W. Schacker, and P. J. Southern (2005)
J. Histochem. Cytochem. 53, 631-642
   Abstract »    Full Text »    PDF »
A Novel and Efficient Approach to Discriminate between Pre- and Post-Transcription HIV Inhibitors.
D. Daelemans, C. Pannecouque, G. N. Pavlakis, O. Tabarrini, and E. De Clercq (2005)
Mol. Pharmacol. 67, 1574-1580
   Abstract »    Full Text »    PDF »
TNF-related apoptosis-inducing ligand (TRAIL) in HIV-1-infected patients and its in vitro production by antigen-presenting cells.
J.-P. Herbeuval, A. Boasso, J.-C. Grivel, A. W. Hardy, S. A. Anderson, M. J. Dolan, C. Chougnet, J. D. Lifson, and G. M. Shearer (2005)
Blood 105, 2458-2464
   Abstract »    Full Text »    PDF »
Anti-Vpr Activity of a Yeast Chaperone Protein.
Z. Benko, D. Liang, E. Agbottah, J. Hou, K. Chiu, M. Yu, S. Innis, P. Reed, W. Kabat, R. T. Elder, et al. (2004)
J. Virol. 78, 11016-11029
   Abstract »    Full Text »    PDF »
Persistent Infection with Primate Foamy Virus Type 1 Increases Human Immunodeficiency Virus Type 1 Cell Binding via a Bet-Independent Mechanism.
C. Schiffer, C.-H. Lecellier, A. Mannioui, N. Felix, E. Nelson, J. Lehmann-Che, M.-L. Giron, J. C. Gluckman, A. Saib, and B. Canque (2004)
J. Virol. 78, 11405-11410
   Abstract »    Full Text »    PDF »
A Nonneutralizing Anti-HIV-1 Antibody Turns into a Neutralizing Antibody When Expressed on the Surface of HIV-1-Susceptible Cells: A New Way to Fight HIV.
S.-J. Lee, L. Garza, J. Yao, A. L. Notkins, and P. Zhou (2004)
J. Immunol. 173, 4618-4626
   Abstract »    Full Text »    PDF »
DNA Vaccines against Human Immunodeficiency Virus Type 1 in the Past Decade.
M. Giri, K. E. Ugen, and D. B. Weiner (2004)
Clin. Microbiol. Rev. 17, 370-389
   Abstract »    Full Text »    PDF »
Orally Active Fusion Inhibitor of Respiratory Syncytial Virus.
C. Cianci, K.-L. Yu, K. Combrink, N. Sin, B. Pearce, A. Wang, R. Civiello, S. Voss, G. Luo, K. Kadow, et al. (2004)
Antimicrob. Agents Chemother. 48, 413-422
   Abstract »    Full Text »    PDF »
Development of Resistance against Diketo Derivatives of Human Immunodeficiency Virus Type 1 by Progressive Accumulation of Integrase Mutations.
V. Fikkert, B. Van Maele, J. Vercammen, A. Hantson, B. Van Remoortel, M. Michiels, C. Gurnari, C. Pannecouque, M. De Maeyer, Y. Engelborghs, et al. (2003)
J. Virol. 77, 11459-11470
   Abstract »    Full Text »    PDF »
Novel Human Immunodeficiency Virus (HIV) Inhibitors That Have a Dual Mode of Anti-HIV Action.
M. Stevens, C. Pannecouque, E. De Clercq, and J. Balzarini (2003)
Antimicrob. Agents Chemother. 47, 3109-3116
   Abstract »    Full Text »    PDF »
Impacts of Avidity and Specificity on the Antiviral Efficiency of HIV-1-Specific CTL.
O. O. Yang, P. T. N. Sarkis, A. Trocha, S. A. Kalams, R. P. Johnson, and B. D. Walker (2003)
J. Immunol. 171, 3718-3724
   Abstract »    Full Text »    PDF »
Inhibition of Human Immunodeficiency Virus by a New Class of Pyridine Oxide Derivatives.
M. Stevens, C. Pannecouque, E. De Clercq, and J. Balzarini (2003)
Antimicrob. Agents Chemother. 47, 2951-2957
   Abstract »    Full Text »    PDF »
Improved Protection of Rhesus Macaques against Intrarectal Simian Immunodeficiency Virus SIVmac251 Challenge by a Replication-Competent Ad5hr-SIVenv/rev and Ad5hr-SIVgag Recombinant Priming/gp120 Boosting Regimen.
J. Zhao, J. Pinczewski, V. R. Gomez-Roman, D. Venzon, V. S. Kalyanaraman, P. D. Markham, K. Aldrich, M. Moake, D. C. Montefiori, Y. Lou, et al. (2003)
J. Virol. 77, 8354-8365
   Abstract »    Full Text »    PDF »
Human Cellular Nucleic Acid-Binding Protein Zn2+ Fingers Support Replication of Human Immunodeficiency Virus Type 1 When They Are Substituted in the Nucleocapsid Protein.
C. F. McGrath, J. S. Buckman, T. D. Gagliardi, W. J. Bosche, L. V. Coren, and R. J. Gorelick (2003)
J. Virol. 77, 8524-8531
   Abstract »    Full Text »    PDF »
Determinants of HIV-1 Mutational Escape From Cytotoxic T Lymphocytes.
O. O. Yang, P. T. N. Sarkis, A. Ali, J. D. Harlow, C. Brander, S. A. Kalams, and B. D. Walker (2003)
J. Exp. Med. 197, 1365-1375
   Abstract »    Full Text »    PDF »
Inhibition of Tat-mediated Transactivation and HIV-1 Replication by Human Anti-hCyclinT1 Intrabodies.
J. Bai, J. Sui, R. Y. Zhu, A. St. C. Tallarico, F. Gennari, D. Zhang, and W. A. Marasco (2003)
J. Biol. Chem. 278, 1433-1442
   Abstract »    Full Text »    PDF »
Actinomycin D Induces High-Level Resistance to Thymidine Analogs in Replication of Human Immunodeficiency Virus Type 1 by Interfering with Host Cell Thymidine Kinase Expression.
T. Imamichi, M. A. Murphy, J. W. Adelsberger, J. Yang, C. M. Watkins, S. C. Berg, M. W. Baseler, R. A. Lempicki, J. Guo, J. G. Levin, et al. (2002)
J. Virol. 77, 1011-1020
   Abstract »    Full Text »    PDF »
Productive Infection of Plasmacytoid Dendritic Cells with Human Immunodeficiency Virus Type 1 Is Triggered by CD40 Ligation.
L. Fong, M. Mengozzi, N. W. Abbey, B. G. Herndier, and E. G. Engleman (2002)
J. Virol. 76, 11033-11041
   Abstract »    Full Text »    PDF »
Characterization of a human immunodeficiency virus type 1 pre-integration complex in which the majority of the cDNA is resistant to DNase I digestion.
D. K. Khiytani and N. J. Dimmock (2002)
J. Gen. Virol. 83, 2523-2532
   Abstract »    Full Text »    PDF »
Antiretrovirus Activity of a Novel Class of Acyclic Pyrimidine Nucleoside Phosphonates.
J. Balzarini, C. Pannecouque, E. De Clercq, S. Aquaro, C.-F. Perno, H. Egberink, and A. Holy (2002)
Antimicrob. Agents Chemother. 46, 2185-2193
   Abstract »    Full Text »    PDF »
A Tight-Binding Mode of Inhibition Is Essential for Anti-Human Immunodeficiency Virus Type 1 Virucidal Activity of Nonnucleoside Reverse Transcriptase Inhibitors.
D. Motakis and M. A. Parniak (2002)
Antimicrob. Agents Chemother. 46, 1851-1856
   Abstract »    Full Text »    PDF »
Cytopathic Killing of Peripheral Blood CD4+ T Lymphocytes by Human Immunodeficiency Virus Type 1 Appears Necrotic rather than Apoptotic and Does Not Require env.
M. J. Lenardo, S. B. Angleman, V. Bounkeua, J. Dimas, M. G. Duvall, M. B. Graubard, F. Hornung, M. C. Selkirk, C. K. Speirs, C. Trageser, et al. (2002)
J. Virol. 76, 5082-5093
   Abstract »    Full Text »    PDF »
Mechanism of Human Immunodeficiency Virus-Induced Complement Expression in Astrocytes and Neurons.
C. Speth, T. Schabetsberger, I. Mohsenipour, G. Stockl, R. Wurzner, H. Stoiber, C. Lass-Florl, and M. P. Dierich (2002)
J. Virol. 76, 3179-3188
   Abstract »    Full Text »    PDF »
Nef-Mediated Resistance of Human Immunodeficiency Virus Type 1 to Antiviral Cytotoxic T Lymphocytes.
O. O. Yang, P. T. Nguyen, S. A. Kalams, T. Dorfman, H. G. Gottlinger, S. Stewart, I. S. Y. Chen, S. Threlkeld, and B. D. Walker (2002)
J. Virol. 76, 1626-1631
   Abstract »    Full Text »    PDF »
Oxidative Modifications of Kynostatin-272, a Potent Human Immunodeficiency Virus Type 1 Protease Inhibitor: Potential Mechanism for Altered Activity in Monocytes/Macrophages.
D. A. Davis, E. Read-Connole, K. Pearson, H. M. Fales, F. M. Newcomb, J. Moskovitz, and R. Yarchoan (2002)
Antimicrob. Agents Chemother. 46, 402-408
   Abstract »    Full Text »    PDF »
Induction of Rapid and Extensive beta -Chemokine Synthesis in Macrophages by Human Immunodeficiency Virus Type 1 and gp120, Independently of Their Coreceptor Phenotype.
W. Choe, D. J. Volsky, and M. J. Potash (2001)
J. Virol. 75, 10738-10745
   Abstract »    Full Text »    PDF »
Human Immunodeficiency Virus Type 1 IIIB Selected for Replication In Vivo Exhibits Increased Envelope Glycoproteins in Virions without Alteration in Coreceptor Usage: Separation of In Vivo Replication from Macrophage Tropism.
E. D. Miller, K. M. Duus, M. Townsend, Y. Yi, R. Collman, M. Reitz, and L. Su (2001)
J. Virol. 75, 8498-8506
   Abstract »    Full Text »    PDF »
Human Immunodeficiency Virus Type 1 Replication in the Absence of Integrase-Mediated DNA Recombination: Definition of Permissive and Nonpermissive T-Cell Lines.
N. Nakajima, R. Lu, and A. Engelman (2001)
J. Virol. 75, 7944-7955
   Abstract »    Full Text »    PDF »
Separation of Human Immunodeficiency Virus Type 1 Replication from nef-Mediated Pathogenesis in the Human Thymus.
K. M. Duus, E. D. Miller, J. A. Smith, G. I. Kovalev, and L. Su (2001)
J. Virol. 75, 3916-3924
   Abstract »    Full Text »
Human Immunodeficiency Virus Type 1 Induces Expression of Complement Factors in Human Astrocytes.
C. Speth, G. Stöckl, I. Mohsenipour, R. Würzner, H. Stoiber, C. Lass-Flörl, and M. P. Dierich (2001)
J. Virol. 75, 2604-2615
   Abstract »    Full Text »
Role for Human Immunodeficiency Virus Type 1 Tat Protein in Suppression of Viral Reverse Transcriptase Activity during Late Stages of Viral Replication.
M. Kameoka, L. Rong, M. Götte, C. Liang, R. S. Russell, and M. A. Wainberg (2001)
J. Virol. 75, 2675-2683
   Abstract »    Full Text »
GLI-2 Modulates Retroviral Gene Expression.
M. J. Smith, S. D. Gitlin, C. M. Browning, B. R. Lane, N. M. Clark, N. Shah, S. Rainier, and D. M. Markovitz (2001)
J. Virol. 75, 2301-2313
   Abstract »    Full Text »
Partial Activation and Induction of Apoptosis in CD4+ and CD8+ T Lymphocytes by Conformationally Authentic Noninfectious Human Immunodeficiency Virus Type 1.
M. T. Esser, J. W. Bess Jr., K. Suryanarayana, E. Chertova, D. Marti, M. Carrington, L. O. Arthur, and J. D. Lifson (2001)
J. Virol. 75, 1152-1164
   Abstract »    Full Text »
Polyanionic (i.e., Polysulfonate) Dendrimers Can Inhibit the Replication of Human Immunodeficiency Virus by Interfering with Both Virus Adsorption and Later Steps (Reverse Transcriptase/Integrase) in the Virus Replicative Cycle.
M. Witvrouw, V. Fikkert, W. Pluymers, B. Matthews, K. Mardel, D. Schols, J. Raff, Z. Debyser, E. De Clercq, G. Holan, et al. (2000)
Mol. Pharmacol. 58, 1100-1108
   Abstract »    Full Text »
Intercellular delivery of a herpes simplex virus VP22 fusion protein from cells infected with lentiviral vectors.
Z. Lai, I. Han, G. Zirzow, R. O. Brady, and J. Reiser (2000)
PNAS 97, 11297-11302
   Abstract »    Full Text »    PDF »
Primary macrophages infected by human immunodeficiency virus trigger CD95-mediated apoptosis of uninfected astrocytes.
S. Aquaro, S. Panti, M. C. Caroleo, E. Balestra, A. Cenci, F. Forbici, G. Ippolito, A. Mastino, R. Testi, V. Mollace, et al. (2000)
J. Leukoc. Biol. 68, 429-435
   Abstract »    Full Text »    PDF »
Viral Entry as the Primary Target for the Anti-HIV Activity of Chicoric Acid and Its Tetra-Acetyl Esters.
W. Pluymers, N. Neamati, C. Pannecouque, V. Fikkert, C. Marchand, T. R. Burke Jr., Y. Pommier, D. Schols, E. De Clercq, Z. Debyser, et al. (2000)
Mol. Pharmacol. 58, 641-648
   Abstract »    Full Text »
Performance of a Multiplex Qualitative PCR LCx Assay for Detection of Human Immunodeficiency Virus Type 1 (HIV-1) Group M Subtypes, Group O, and HIV-2.
K. Abravaya, C. Esping, R. Hoenle, J. Gorzowski, R. Perry, P. Kroeger, J. Robinson, and R. Flanders (2000)
J. Clin. Microbiol. 38, 716-723
   Abstract »    Full Text »
PCR-derived ssDNA Probes for Fluorescent In Situ Hybridization to HIV-1 RNA.
M. C. Knuchel, B. Graf, E. Schlaepfer, H. Kuster, M. Fischer, R. Weber, and R. W. Cone (2000)
J. Histochem. Cytochem. 48, 285-294
   Abstract »    Full Text »
Reversal of Human Immunodeficiency Virus Type 1 Protein-Induced Inhibition of Natural Killer Cell Activity by Alpha Interferon and Interleukin-2.
M. P. N. Nair and S. A. Schwartz (2000)
Clin. Vaccine Immunol. 7, 101-105
   Abstract »    Full Text »    PDF »
A Second Target for the Peptoid Tat/Transactivation Response Element Inhibitor CGP64222: Inhibition of Human Immunodeficiency Virus Replication by Blocking CXC-Chemokine Receptor 4-Mediated Virus Entry.
D. Daelemans, D. Schols, M. Witvrouw, C. Pannecouque, S. Hatse, S. van Dooren, F. Hamy, T. Klimkait, E. de Clercq, and A.-M. VanDamme (2000)
Mol. Pharmacol. 57, 116-124
   Abstract »    Full Text »
Determinants of CD4 Independence for a Human Immunodeficiency Virus Type 1 Variant Map outside Regions Required for Coreceptor Specificity.
C. C. LaBranche, T. L. Hoffman, J. Romano, B. S. Haggarty, T. G. Edwards, T. J. Matthews, R. W. Doms, and J. A. Hoxie (1999)
J. Virol. 73, 10310-10319
   Abstract »    Full Text »
Pseudotyping human immunodeficiency virus type 1 by vesicular stomatitis virus G protein does not reduce the cell-dependent requirement of Vif for optimal infectivity: functional difference between Vif and Nef.
H. Akari, T. Uchiyama, T. Fukumori, S. Iida, A. H. Koyama, and A. Adachi (1999)
J. Gen. Virol. 80, 2945-2949
   Abstract »    Full Text »
Anti-Kaposi's Sarcoma and Antiangiogenic Activities of Sulfated Dextrins.
M. Thornton, L. Barkley, J. C. Mason, and S. Shaunak (1999)
Antimicrob. Agents Chemother. 43, 2528-2533
   Abstract »    Full Text »
Primary Human Immunodeficiency Virus Type 2 (HIV-2) Isolates Infect CD4-Negative Cells via CCR5 and CXCR4: Comparison with HIV-1 and Simian Immunodeficiency Virus and Relevance to Cell Tropism In Vivo.
J. D. Reeves, S. Hibbitts, G. Simmons, A. McKnight, J. M. Azevedo-Pereira, J. Moniz-Pereira, and P. R. Clapham (1999)
J. Virol. 73, 7795-7804
   Abstract »    Full Text »
Natural experimental models: The global search for biomedical paradigms among traditional, modernizing, and modern populations.
R. M. Garruto, M. A. Little, G. D. James, and D. E. Brown (1999)
PNAS 96, 10536-10543
   Abstract »    Full Text »    PDF »
Multiplex detection of four pathogenic retroviruses using molecular beacons.
J. A. M. Vet, A. R. Majithia, S. A. E. Marras, S. Tyagi, S. Dube, B. J. Poiesz, and F. R. Kramer (1999)
PNAS 96, 6394-6399
   Abstract »    Full Text »    PDF »
Evaluation of a Rapid Immunochromatographic Test for Detection of Antibodies to Human Immunodeficiency Virus.
H. Arai, B. Petchclai, K. Khupulsup, T. Kurimura, and K. Takeda (1999)
J. Clin. Microbiol. 37, 367-370
   Abstract »    Full Text »
CD4+ T-Lymphocyte Depletion in Human Lymphoid Tissue Ex Vivo Is Not Induced by Noninfectious Human Immunodeficiency Virus Type 1 Virions.
A. W. Sylwester, J.-C. Grivel, W. Fitzgerald, J. L. Rossio, J. D. Lifson, and L. B. Margolis (1998)
J. Virol. 72, 9345-9347
   Abstract »    Full Text »    PDF »
Selective Inhibition of HIV-1 Reverse Transcriptase by an Antiviral Inhibitor, (R)-9-(2-Phosphonylmethoxypropyl)adenine.
Z. Suo and K. A. Johnson (1998)
J. Biol. Chem. 273, 27250-27258
   Abstract »    Full Text »    PDF »
Chronically HIV-1-Infected Monocytic Cells Induce Apoptosis in Cocultured T Cells.
H. Chen, Y. K. Yip, I. George, M. Tyorkin, E. Salik, and K. Sperber (1998)
J. Immunol. 161, 4257-4267
   Abstract »    Full Text »    PDF »
Common Themes of Antibody Maturation to Simian Immunodeficiency Virus, Simian-Human Immunodeficiency Virus, and Human Immunodeficiency Virus Type 1 Infections.
K. S. Cole, M. Murphey-Corb, O. Narayan, S. V. Joag, G. M. Shaw, and R. C. Montelaro (1998)
J. Virol. 72, 7852-7859
   Abstract »    Full Text »    PDF »
Dissociation of the CD4 and CXCR4 Binding Properties of Human Immunodeficiency Virus Type 1 gp120 by Deletion of the First Putative Alpha-Helical Conserved Structure.
D. Misse, M. Cerutti, I. Schmidt, A. Jansen, G. Devauchelle, F. Jansen, and F. Veas (1998)
J. Virol. 72, 7280-7288
   Abstract »    Full Text »    PDF »
Continued Utilization of CCR5 Coreceptor by a Newly Derived T-Cell Line-Adapted Isolate of Human Immunodeficiency Virus Type 1.
K. E. Follis, M. Trahey, R. A. LaCasse, and J. H. Nunberg (1998)
J. Virol. 72, 7603-7608
   Abstract »    Full Text »    PDF »
The leukotriene B4 receptor functions as a novel type of coreceptor mediating entry of primary HIV-1 isolates into CD4-positive cells.
C. Owman, A. Garzino-Demo, F. Cocchi, M. Popovic, A. Sabirsh, and R. C. Gallo (1998)
PNAS 95, 9530-9534
   Abstract »    Full Text »    PDF »
Determinants of Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Activation by Soluble CD4 and Monoclonal Antibodies.
N. Sullivan, Y. Sun, J. Binley, J. Lee, C. F. Barbas III, P. W. H. I. Parren, D. R. Burton, and J. Sodroski (1998)
J. Virol. 72, 6332-6338
   Abstract »    Full Text »    PDF »
Human Immunodeficiency Virus Type 1 Replication Is Modulated by Host Cyclophilin A Expression Levels.
L. Yin, D. Braaten, and J. Luban (1998)
J. Virol. 72, 6430-6436
   Abstract »    Full Text »    PDF »
CD4-Induced Conformational Changes in the Human Immunodeficiency Virus Type 1 gp120 Glycoprotein: Consequences for Virus Entry and Neutralization.
N. Sullivan, Y. Sun, Q. Sattentau, M. Thali, D. Wu, G. Denisova, J. Gershoni, J. Robinson, J. Moore, and J. Sodroski (1998)
J. Virol. 72, 4694-4703
   Abstract »    Full Text »    PDF »
Novel Inhibitory Effects of gamma -Glutamylcysteine Ethyl Ester against Human Immunodeficiency Virus Type 1 Production and Propagation.
S. Kubota, S. Shetty, H. Zhang, S. Kitahara, and R. J. Pomerantz (1998)
Antimicrob. Agents Chemother. 42, 1200-1206
   Abstract »    Full Text »
Characterization of V3 Loop-Pseudomonas Exotoxin Chimeras. CANDIDATE VACCINES FOR HUMAN IMMUNODEFICIENCY VIRUS-1.
D. J. FitzGerald, C. M. Fryling, M. L. McKee, J. C. Vennari, T. Wrin, M. E. M. Cromwell, A. L. Daugherty, and R. J. Mrsny (1998)
J. Biol. Chem. 273, 9951-9958
   Abstract »    Full Text »    PDF »
Cleavage of Human Immunodeficiency Virus Type 1 Proteinase from the N-Terminally Adjacent p6* Protein Is Essential for Efficient Gag Polyprotein Processing and Viral Infectivity.
U. Tessmer and H.-G. Krausslich (1998)
J. Virol. 72, 3459-3463
   Abstract »    Full Text »    PDF »
The Lipophosphoglycan of Leishmania donovani Up-Regulates HIV-1 Transcription in T Cells Through the Nuclear Factor-{kappa}B Elements.
R. Bernier, B. Barbeau, M. J. Tremblay, and M. Olivier (1998)
J. Immunol. 160, 2881-2888
   Abstract »    Full Text »    PDF »
1,1,3-Trioxo-2H,4H-Thieno[3,4-e][1,2,4]Thiadiazine (TTD) Derivatives: a New Class of Nonnucleoside Human Immunodeficiency Virus Type 1 (HIV-1) Reverse Transcriptase Inhibitors with Anti-HIV-1 Activity.
M. Witvrouw, M. E. Arranz, C. Pannecouque, R. Declercq, H. Jonckheere, J.-C. Schmit, A.-M. Vandamme, J. A. Diaz, S. T. Ingate, J. Desmyter, et al. (1998)
Antimicrob. Agents Chemother. 42, 618-623
   Abstract »    Full Text »
Nucleocapsid and Matrix Protein Contributions to Selective Human Immunodeficiency Virus Type 1 Genomic RNA Packaging.
D. T. K. Poon, G. Li, and A. Aldovini (1998)
J. Virol. 72, 1983-1993
   Abstract »    Full Text »    PDF »
Evolution of a Simian Immunodeficiency Virus Pathogen.
P. Edmonson, M. Murphey-Corb, L. N. Martin, C. Delahunty, J. Heeney, H. Kornfeld, P. R. Donahue, G. H. Learn, L. Hood, and J. I. Mullins (1998)
J. Virol. 72, 405-414
   Abstract »    Full Text »    PDF »
Spontaneous Mutations in the env Gene of the Human Immunodeficiency Virus Type 1 NDK Isolate Are Associated with a CD4-Independent Entry Phenotype.
J. Dumonceaux, S. Nisole, C. Chanel, L. Quivet, A. Amara, P. Briand, and U. Hazan (1998)
J. Virol. 72, 512-519
   Abstract »    Full Text »    PDF »
Mutations in HIV reverse transcriptase which alter RNase H activity and decrease strand transfer efficiency are suppressed by HIV nucleocapsid protein.
C. E. Cameron, M. Ghosh, S. F. J. Le Grice, and S. J. Benkovic (1997)
PNAS 94, 6700-6705
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)