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Science 20 April 1984:
Vol. 224. no. 4646, pp. 256 - 262
DOI: 10.1126/science.6538699
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Articles

Science, Vol 224, Issue 4646, 256-262
Copyright © 1984 by American Association for the Advancement of Science

articles

Expression of cellular oncogenes in human malignancies

DJ Slamon, JB deKernion, IM Verma, and MJ Cline

Cellular oncogenes have been implicated in the induction of malignant transformation in some model systems in vitro and may be related to malignancies in vivo in some vertebrate species. This article describes a study of the expression of 15 cellular oncogenes in fresh human tumors from 54 patients, representing 20 different tumor types. More than one cellular oncogene was transcriptionally active in all of the tumors examined. In 14 patients it was possible to study normal and malignant tissue from the same organ. In many of these patients, the transcriptional activity of certain oncogenes was greater in the malignant than the normal tissue. The cellular fes (feline sarcoma) oncogene, not previously known to be transcribed in mammalian tissue, was found to be active in lung and hematopoietic malignancies.


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Autoimmunity and increased c-myb transcription.
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Oncogenes: Implications for the Diagnosis and Treatment of Cancer.
M. J. CLINE, D. J. SLAMON, and J. S. LIPSICK (1984)
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