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Science 13 April 1984:
Vol. 224. no. 4645, pp. 168 - 171
DOI: 10.1126/science.6142531
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Articles

Science, Vol 224, Issue 4645, 168-171
Copyright © 1984 by American Association for the Advancement of Science

articles

Sequence of the human somatostatin I gene

LP Shen and WJ Rutter

Two human genomic DNA fragments containing alleles for the gene coding for somatostatin I were isolated and sequenced. This gene contains a single intron that interrupts the coding sequence in the propeptide portion of the somatostatin moiety. The site of initiation of transcription of the gene was located by transcription experiments in HeLa cell extracts, and the putative regions for controlling the initiation of transcription were identified.


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Expression of Three Distinct Somatostatin Messenger Ribonucleic Acids (mRNAs) in Goldfish Brain: Characterization of the Complementary Deoxyribonucleic Acids, Distribution and Seasonal Variation of the mRNAs, and Action of a Somatostatin-14 Variant.
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Differential Processing of Proglucagon by the Subtilisin-like Prohormone Convertases PC2 and PC3 to Generate either Glucagon or Glucagon-like Peptide.
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Reduction to homozygosity of genes on chromosome 11 in human breast neoplasia.
I. Ali, R Lidereau, C Theillet, and R Callahan (1987)
Science 238, 185-188
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Cell-specific expression of the rat insulin gene: evidence for role of two distinct 5' flanking elements.
T Edlund, M. Walker, P. Barr, and W. Rutter (1985)
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