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Science 6 April 1984:
Vol. 224. no. 4644, pp. 22 - 31
DOI: 10.1126/science.6322304
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Articles

Science, Vol 224, Issue 4644, 22-31
Copyright © 1984 by American Association for the Advancement of Science

articles

Drug and neurotransmitter receptors in the brain

SH Snyder

Biochemical investigation of receptors for neurotransmitters and drugs in the brain has been one of the most active areas of molecular neuroscience during the past decade. This work has permitted fundamental insights into how binding of neurotransmitters to their receptors excites or inhibits neuronal firing or changes cellular metabolism. The recognition of receptor subtypes has suggested subtle ways for neurotransmitters to modulate neuronal functioning. Finally, the ability to measure receptor sites in simple test tube systems and to distinguish readily between agonists and antagonists has provided useful probes for drug discovery programs.


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Extending neurotransmitter hypotheses of neuroleptic action and schizophrenia beyond cell-surface receptors. The phosphoinositide signalling system provides a link between receptors and intracellular calcium.
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The Effect of Beta Blockade on Stress-Induced Cognitive Dysfunction in Adolescents.
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Clinical Pediatrics 30, 441-445
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Excessive Water Drinking: A Marker of Caretaker Interaction Disturbance.
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Clinical Pediatrics 28, 416-418
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The coupling of neurotransmitter receptors to ion channels in the brain.
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Imaging of Neurotransmitter Receptors in the Living Human Brain.
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Neurosciences: an integrative discipline.
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Acetylcholine receptor: an allosteric protein.
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Message transmission: receptor controlled adenylate cyclase system.
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