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Science 30 March 1984:
Vol. 223. no. 4643, pp. 1415 - 1417
DOI: 10.1126/science.6322302
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Articles

Science, Vol 223, Issue 4643, 1415-1417
Copyright © 1984 by American Association for the Advancement of Science

articles

Increased phosphorylation of myosin light chain kinase after an increase in cyclic AMP in intact smooth muscle

P de Lanerolle, M Nishikawa, DA Yost, and RS Adelstein

The role of cyclic adenosine monophosphate-mediated phosphorylation of myosin light chain kinase in relaxing smooth muscle was examined. The kinase was immunoprecipitated from tissue extracts and the phosphate content was determined. The addition of forskolin to resting or methacholine-contracted muscles resulted in an increase in myosin light chain kinase phosphorylation of myosin light chain kinase is one of the reactions in the process by which cyclic adenosine monophosphate causes relaxation of smooth muscle.


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