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Science 23 March 1984:
Vol. 223. no. 4642, pp. 1309 - 1312
DOI: 10.1126/science.6322301
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Articles

Science, Vol 223, Issue 4642, 1309-1312
Copyright © 1984 by American Association for the Advancement of Science

articles

Transfusion-associated AIDS: serologic evidence of human T-cell leukemia virus infection of donors

HW Jaffe, DP Francis, MF McLane, C Cabradilla, JW Curran, BW Kilbourne, DN Lawrence, HW Haverkos, TJ Spira, RY Dodd, and al. et

An assay for antibodies to membrane antigens of cells infected by human T-cell leukemia virus was used to examine serum from persons who donated blood to 12 patients with acquired immunodeficiency syndrome (AIDS) associated with blood transfusions. The occurrence of positive results in the assay was significantly greater among donors to the AIDS patients (9 of 117; 7.7 percent) than among random donors (1 of 298; 0.3 percent). Of 12 sets of donors examined, 9 sets included a donor whose serum gave positive results for the presence of the antibodies. In six of these nine sets, the seropositive donor was an individual who was also identified as a possible source of AIDS transmission when epidemiologic and immunologic criteria were used.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Antigens of Human T-Lymphotropic Virus Type III/Lymphadenopathy-Associated Virus.
M. ESSEX, J. ALLAN, P. KANKI, M. F. McLANE, G. MALONE, L. KITCHEN, and T. H. LEE (1985)
Ann Intern Med 103, 700-703
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Absence of Antibodies to HTLV-III in Health Workers After Hepatitis B Vaccination.
J. L. Dienstag, B. G. Werner, M. F. McLane, D. R. Snydman, G. F. Grady, D. E. Craven, C. S. Crumpacker, B. F. Polk, R. Platt, J. Allan, et al. (1985)
JAMA 254, 1064-1066
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Infection With HTLV-III/LAV and Transfusion-Associated Acquired Immunodeficiency Syndrome: Serologic Evidence of an Association.
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Major glycoprotein antigens that induce antibodies in AIDS patients are encoded by HTLV-III.
J. Allan, J. Coligan, F Barin, M. McLane, J. Sodroski, C. Rosen, W. Haseltine, T. Lee, and M Essex (1985)
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Suppression of gamma interferon production by inactivated feline leukemia virus.
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Apparent Transmission of Human T-Cell Leukemia Virus Type III to a Heterosexual Woman with the Acquired Immunodeficiency Syndrome.
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Transmission of HTLV-III infection from human plasma to chimpanzees: an animal model for AIDS.
H. Alter, J. Eichberg, H Masur, W. Saxinger, R Gallo, A. Macher, H. Lane, and A. Fauci (1984)
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HTLV-III in saliva of people with AIDS-related complex and healthy homosexual men at risk for AIDS.
J. Groopman, S. Salahuddin, M. Sarngadharan, P. Markham, M Gonda, A Sliski, and R. Gallo (1984)
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Lymphadenopathy associated virus infection of a blood donor--recipient pair with acquired immunodeficiency syndrome.
P. Feorino, V. Kalyanaraman, H. Haverkos, C. Cabradilla, D. Warfield, H. Jaffe, A. Harrison, M. Gottlieb, D Goldfinger, J. Chermann, et al. (1984)
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Serological analysis of a subgroup of human T-lymphotropic retroviruses (HTLV-III) associated with AIDS.
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