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Science 16 March 1984:
Vol. 223. no. 4641, pp. 1197 - 1199
DOI: 10.1126/science.6322298
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Articles

Science, Vol 223, Issue 4641, 1197-1199
Copyright © 1984 by American Association for the Advancement of Science

articles

A transforming ras gene in tumorigenic guinea pig cell lines initiated by diverse chemical carcinogens

S Sukumar, S Pulciani, J Doniger, JA DiPaolo, CH Evans, B Zbar, and M Barbacid

Fetal guinea pig cells were transformed by treatment with four different chemical carcinogens including nitroso compounds and polycyclic hydrocarbons. As a consequence of this treatment, oncogenes capable of transforming NIH/3T3 cells became activated in each of five independently established clonal guinea pig cell lines. Molecular characterization of representative NIH/3T3 transformants revealed that the same oncogene was present in each of the cell lines tested. Moreover, detection of this transforming gene paralleled the acquisition of tumorigenic properties by these neoplastic cells.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Biomarkers for Early Detection of Colon Cancer.
S. Srivastava, M. Verma, and D. E. Henson (2001)
Clin. Cancer Res. 7, 1118-1126
   Abstract »    Full Text »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)