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Science 16 March 1984:
Vol. 223. no. 4641, pp. 1193 - 1195
DOI: 10.1126/science.6199843
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Articles

Science, Vol 223, Issue 4641, 1193-1195
Copyright © 1984 by American Association for the Advancement of Science

articles

The enzymatic synthesis of 5-amino-4-imidazolecarboxamide riboside triphosphate (ZTP)

RL Sabina, EW Holmes, and MA Becker

5-Amino-4-imidazolecarboxamide riboside triphosphate (ZTP) is thought to play a regulatory role in cellular metabolism. Unlike other nucleoside triphosphates, ZTP is synthesized in a one-step reaction in which the pyrophosphate group of 5-phosphoribosyl-l-pyrophosphate is transferred to the riboside monophosphate (ZMP) in a reaction catalyzed by 5-phosphoribosyl-l-pyrophosphate synthetase; reversal of this reaction leads to dephosphorylation of ZTP to ZMP. This unusual route of synthesis (and catabolism) of ZTP may be important in defining its metabolic effects in the cell.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)