Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 9 March 1984:
Vol. 223. no. 4640, pp. 1079 - 1082
DOI: 10.1126/science.6320373
Prev | Table of Contents | Next

Articles

Science, Vol 223, Issue 4640, 1079-1082
Copyright © 1984 by American Association for the Advancement of Science

articles

Rat transforming growth factor type 1: structure and relation to epidermal growth factor

H Marquardt, MW Hunkapiller, LE Hood, and GJ Todaro

The complete amino acid sequence of rat transforming growth factor type 1 has been determined. This growth factor, obtained from retrovirus-transformed fibroblasts, is structurally and functionally related to mouse epidermal growth factor and human urogastrone. Production of this polypeptide by various neoplastic cells might contribute to the continued expression of the transformed phenotype.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Expression of the Arf tumor suppressor gene is controlled by Tgf{beta}2 during development.
N. E. Freeman-Anderson, Y. Zheng, A. C. McCalla-Martin, L. M. Treanor, Y. D. Zhao, P. M. Garfin, T.-C. He, M. N. Mary, J. D. Thornton, C. Anderson, et al. (2009)
Development 136, 2081-2089
   Abstract »    Full Text »    PDF »
Phenotypic Variation Resulting From a Deficiency of Epidermal Growth Factor Receptor in Mice Is Caused by Extensive Genetic Heterogeneity That Can Be Genetically and Molecularly Partitioned.
K. E. Strunk, V. Amann, and D. W. Threadgill (2004)
Genetics 167, 1821-1832
   Abstract »    Full Text »    PDF »
Cigarette smoke induces MUC5AC mucin overproduction via tumor necrosis factor-{alpha}-converting enzyme in human airway epithelial (NCI-H292) cells.
M. X. G. Shao, T. Nakanaga, and J. A. Nadel (2004)
Am J Physiol Lung Cell Mol Physiol 287, L420-L427
   Abstract »    Full Text »    PDF »
Tumor necrosis factor {alpha}-converting enzyme mediates MUC5AC mucin expression in cultured human airway epithelial cells.
M. X. G. Shao, I. F. Ueki, and J. A. Nadel (2003)
PNAS 100, 11618-11623
   Abstract »    Full Text »    PDF »
Ligand-independent Dimer Formation of Epidermal Growth Factor Receptor (EGFR) Is a Step Separable from Ligand-induced EGFR Signaling.
X. Yu, K. D. Sharma, T. Takahashi, R. Iwamoto, and E. Mekada (2002)
Mol. Biol. Cell 13, 2547-2557
   Abstract »    Full Text »    PDF »
Tumor Necrosis Factor-alpha Converting Enzyme (TACE) Regulates Epidermal Growth Factor Receptor Ligand Availability.
S. W. Sunnarborg, C. L. Hinkle, M. Stevenson, W. E. Russell, C. S. Raska, J. J. Peschon, B. J. Castner, M. J. Gerhart, R. J. Paxton, R. A. Black, et al. (2002)
J. Biol. Chem. 277, 12838-12845
   Abstract »    Full Text »    PDF »
Role of Transforming Growth Factor-{alpha} and the Epidermal Growth Factor Receptor in Embryonic Rat Testis Development.
E. Levine, A. S. Cupp, L. Miyashiro, and M. K. Skinner (2000)
Biol Reprod 62, 477-490
   Abstract »    Full Text »
Epiregulin, a Novel Member of the Epidermal Growth Factor Family, Is an Autocrine Growth Factor in Normal Human Keratinocytes.
Y. Shirakata, T. Komurasaki, H. Toyoda, Y. Hanakawa, K. Yamasaki, S. Tokumaru, K. Sayama, and K. Hashimoto (2000)
J. Biol. Chem. 275, 5748-5753
   Abstract »    Full Text »    PDF »
Role of Ovarian Theca and Granulosa Cell Interaction in Hormone Productionand Cell Growth During the Bovine Follicular Maturation Process.
H. Yada, K. Hosokawa, K. Tajima, Y. Hasegawa, and F. Kotsuji (1999)
Biol Reprod 61, 1480-1486
   Abstract »    Full Text »
A Differential Requirement for the COOH-terminal Region of the Epidermal Growth Factor (EGF) Receptor in Amphiregulin and EGF Mitogenic Signaling.
L. Wong, T. B. Deb, S. A. Thompson, A. Wells, and G. R. Johnson (1999)
J. Biol. Chem. 274, 8900-8909
   Abstract »    Full Text »    PDF »
Biological Response to ErbB Ligands in Nontransformed Cell Lines Correlates with a Specific Pattern of Receptor Expression.
S. Sundaresan, P. E. Roberts, K. L. King, M. X. Sliwkowski, and J. P. Mather (1998)
Endocrinology 139, 4756-4764
   Abstract »    Full Text »    PDF »
Evidence of Juxtacrine Signaling for Transforming Growth Factor {alpha} inHuman Endometrium.
M. R. Bush, J. M. Mele, G. M. Couchman, and D. K. Walmer (1998)
Biol Reprod 59, 1522-1529
   Abstract »    Full Text »
Elevated Transforming Growth Factor-alpha Levels in Bronchoalveolar Lavage Fluid of Patients with Acute Respiratory Distress Syndrome.
D. K. MADTES, G. RUBENFELD, L. D. KLIMA, J. A. MILBERG, K. P. STEINBERG, T. R. MARTIN, G. RAGHU, L. D. HUDSON, and J. G. CLARK (1998)
Am. J. Respir. Crit. Care Med. 158, 424-430
   Abstract »    Full Text »    PDF »
TGF{alpha} is Dispensable for Skin Tumorigenesis in Tg.AC Mice.
M. C. Humble, C. J. Szczesniak, N. C. Luetteke, J. W. Spalding, R. E. Cannon, L. A. Hansen, D. C. Lee, and R. W. Tennant (1998)
Toxicol Pathol 26, 562-569
   Abstract »    PDF »
ErbB2 expression increases the spectrum and potency of ligand-mediated signal transduction through ErbB4.
L.-M. Wang, A. Kuo, M. Alimandi, M. C. Veri, C.-C. Lee, V. Kapoor, N. Ellmore, X.-H. Chen, and J. H. Pierce (1998)
PNAS 95, 6809-6814
   Abstract »    Full Text »    PDF »
Transforming Growth Factor-alpha Null and Senescent Mice Show Decreased Neural Progenitor Cell Proliferation in the Forebrain Subependyma.
V. Tropepe, C. G. Craig, C. M. Morshead, and D. van der Kooy (1997)
J. Neurosci. 17, 7850-7859
   Abstract »    Full Text »    PDF »
Increased expression of transforming growth factor alpha  precursors in acute experimental colitis in rats.
P Hoffmann, J M Zeeh, J Lakshmanan, V S Wu, F Procaccino, M Reinshagen, J A McRoberts, and V E Eysselein (1997)
Gut 41, 195-202
   Abstract »    Full Text »    PDF »
Transcription Factor AP-2 Controls Transcription of the Human Transforming Growth Factor-alpha Gene.
D. Wang, T. H. Shin, and J. E. Kudlow (1997)
J. Biol. Chem. 272, 14244-14250
   Abstract »    Full Text »    PDF »
Chicken Acidic Leucine-rich EGF-like Domain Containing Brain Protein (CALEB), a Neural Member of the EGF Family of Differentiation Factors, Is Implicated in Neurite Formation.
S. Schumacher, H. Volkmer, F. Buck, A. Otto, A. Tarnok, S. Roth, and F. G. Rathjen (1997)
J. Cell Biol. 136, 895-906
   Abstract »    Full Text »    PDF »
Cryptic Gonadotropin-Releasing Hormone Receptors of Rat Pituitary Cells in Culture Are Unmasked by Epidermal Growth Factor.
P. Leblanc, A. L'Heritier, and C. Kordon (1997)
Endocrinology 138, 574-579
   Abstract »    Full Text »    PDF »
Cysteines 153 and 154 of Transmembrane Transforming Growth Factor-alpha Are Palmitoylated and Mediate Cytoplasmic Protein Association.
L. Shum, C. W. Turck, and R. Derynck (1996)
J. Biol. Chem. 271, 28502-28508
   Abstract »    Full Text »    PDF »
Vein is a novel component in the Drosophila epidermal growth factor receptor pathway with similarity to the neuregulins..
B Schnepp, G Grumbling, T Donaldson, and A Simcox (1996)
Genes & Dev. 10, 2302-2313
   Abstract »    PDF »
Epiregulin.
H. Toyoda, T. Komurasaki, D. Uchida, Y. Takayama, T. Isobe, T. Okuyama, and K. Hanada (1995)
J. Biol. Chem. 270, 7495-7500
   Abstract »    Full Text »    PDF »
The mouse waved-2 phenotype results from a point mutation in the EGF receptor tyrosine kinase..
N C Luetteke, H K Phillips, T H Qiu, N G Copeland, H S Earp, N A Jenkins, and D C Lee (1994)
Genes & Dev. 8, 399-413
   Abstract »    PDF »
Betacellulin: a mitogen from pancreatic beta cell tumors.
Y Shing, G Christofori, D Hanahan, Y Ono, R Sasada, K Igarashi, and J Folkman (1993)
Science 259, 1604-1607
   Abstract »    PDF »
Interaction between The Neural Crest and Extracellular Matrix Proteins in Craniofacial Skeletogenesis.
M. Mina, E. J. Kollar, J. A. Bishop, and D. H. Rohrbach (1990)
Critical Reviews in Oral Biology & Medicine 1, 79-87
   Full Text »    PDF »
Unusual pattern of accumulation of mRNA encoding EGF-related protein in sea urchin embryos.
Q Yang, L. Angerer, and R. Angerer (1989)
Science 246, 806-808
   Abstract »    PDF »
Structure and function of human amphiregulin: a member of the epidermal growth factor family.
M Shoyab, G. Plowman, V. McDonald, J. Bradley, and G. Todaro (1989)
Science 243, 1074-1076
   Abstract »    PDF »
A sea urchin gene encodes a polypeptide homologous to epidermal growth factor.
D. Hursh, M. Andrews, and R. Raff (1987)
Science 237, 1487-1490
   Abstract »    PDF »
Angiogenic factors.
J Folkman and M Klagsbrun (1987)
Science 235, 442-447
   Abstract »    PDF »
Inhibition of endothelial regeneration by type-beta transforming growth factor from platelets.
R. Heimark, D. Twardzik, and S. Schwartz (1986)
Science 233, 1078-1080
   Abstract »    PDF »
Transforming growth factor-alpha: a more potent angiogenic mediator than epidermal growth factor.
A. Schreiber, M. Winkler, and R Derynck (1986)
Science 232, 1250-1253
   Abstract »    PDF »
Endogeneous and Heterologous Expression of Transforming Growth Factor-{alpha} in Mammalian Cells.
R. Derynck, A. Rosenthal, P.B. Lindquist, T.S. Bringman, and D.V. Goeddel (1986)
Cold Spring Harb Symp Quant Biol 51, 649-655
   Abstract »    PDF »
Physiological effects of transforming growth factor in the newborn mouse.
J. Tam (1985)
Science 229, 673-675
   Abstract »    PDF »
Growth inhibitor from BSC-1 cells closely related to platelet type beta transforming growth factor.
R. Tucker, G. Shipley, H. Moses, and R. Holley (1984)
Science 226, 705-707
   Abstract »    PDF »
Contemporary methodology for protein structure determination.
M. Hunkapiller, J. Strickler, and K. Wilson (1984)
Science 226, 304-311
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)