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Science 2 March 1984:
Vol. 223. no. 4639, pp. 930 - 931
DOI: 10.1126/science.6198721
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Articles

Science, Vol 223, Issue 4639, 930-931
Copyright © 1984 by American Association for the Advancement of Science

articles

Antibody to hepatitis B virus induced by injecting antibodies to the idiotype

RC Kennedy, JL Melnick, and GR Dreesman

Anti-idiotype reagents that recognize a common idiotype associated with antibody to hepatitis B surface antigen (anti-HBs) were used to induce anti-HBs in mice. The anti-idiotype-induced anti-HBs was found to recognize the group-specific a determinant of hepatitis B surface antigen and to express an interspecies idiotype. These findings suggest that anti-idiotypes may be useful as vaccines or vaccine primers.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)