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Science 2 March 1984:
Vol. 223. no. 4639, pp. 883 - 887
DOI: 10.1126/science.223.4639.883
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Articles

Free-Radical Carbon-Carbon Bond Formation in Organic Synthesis

David J. Hart 1

1 Associate professor in the Department of Chemistry, Ohio State University, Columbus 43210.

Organic chemists have begun to use intra- and intermolecular free-radical addition reactions to develop useful synthetic transformations. Carboncentered radicals can form bonds with electron-rich or electron-deficient alkenes, allenes, and acetylenes. Radical addition reactions can also be used to construct hindered carbon-carbon bonds. These characteristics, as well as the large number of functional groups that tolerate free-radical conditions contribute to the importance of such reactions in organic synthesis.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)