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Science 24 February 1984:
Vol. 223. no. 4638, pp. 833 - 835
DOI: 10.1126/science.6546454
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Articles

Science, Vol 223, Issue 4638, 833-835
Copyright © 1984 by American Association for the Advancement of Science

articles

Avian pancreatic polypeptide phase shifts hamster circadian rhythms when microinjected into the suprachiasmatic region

HE Albers, CF Ferris, SE Leeman, and BD Goldman

The suprachiasmatic nucleus has been identified tentatively as a circadian pacemaker. To examine the functional role of peptides found within suprachiasmatic neurons, avian pancreatic polypeptide and vasopressin were microinjected into the suprachiasmatic region. Avian pancreatic polypeptide, but not vasopressin, shifted the phase of the wheelrunning rhythm as a function of the time of its injection within the circadian cycle. Avian pancreatic polypeptide or a similar peptide may be one component of the neurochemical processes underlying entrainment to the light-dark cycle.


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