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Science 24 February 1984:
Vol. 223. no. 4638, pp. 825 - 828
DOI: 10.1126/science.6420890
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Articles

Science, Vol 223, Issue 4638, 825-828
Copyright © 1984 by American Association for the Advancement of Science

articles

Functional expression of a cloned I-A beta k gene in B-lymphoma cells

A Ben-Nun, LH Glimcher, J Weis, and JG Seidman

The immune response genes of the mouse encode two cell-surface glycoproteins, I-A and I-E, that play critical roles in determining the animal's immune responsiveness. The I-A antigen contains two chains, alpha and beta. A cloned beta-chain gene, I-A beta k, was introduced into B-lymphoma cells that express I-Ad. The transfected gene was successfully expressed on the cell surface of the recipient cells and was functional in stimulating allospecific T cells.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)