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Science 24 February 1984:
Vol. 223. no. 4638, pp. 813 - 816
DOI: 10.1126/science.6320371
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Articles

Science, Vol 223, Issue 4638, 813-816
Copyright © 1984 by American Association for the Advancement of Science

articles

A common onc gene sequence transduced by avian carcinoma virus MH2 and by murine sarcoma virus 3611

NC Kan, CS Flordellis, GE Mark, PH Duesberg, and TS Papas

A common cellular sequence was independently transduced by avian carcinoma virus MH2 (v-mht) and murine sarcoma virus (MSV) 3611 (v-raf). Comparison of the nucleotide sequences of v-mht and v-raf revealed a region of homology that extends over 969 nucleotides. The homology between the corresponding amino acids was about 95 percent with only 19 of 323 amino acids being different. With this example, 5 of the 19 known different viral onc genes have been observed in viruses of different taxonomic groups. These data indicate that (i) the number of cellular proto-onc genes is limited because, like other viruses of different taxonomic groups, MH2 and MSV 3611 have transduced the same onc gene-specific sequences from different cell species and (ii) that specific deletion and linkage of the same proto-onc sequences to different viral vector elements affect the oncogenic potential of the resulting viruses. The difference in transformation capabilities of MH2 and MSV 3611 serves as an example.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Raf: A Strategic Target for Therapeutic Development Against Cancer.
M. Beeram, A. Patnaik, and E. K. Rowinsky (2005)
J. Clin. Oncol. 23, 6771-6790
   Abstract »    Full Text »    PDF »
The raf oncogene is associated with a radiation-resistant human laryngeal cancer.
U Kasid, A Pfeifer, R. Weichselbaum, A Dritschilo, and G. Mark (1987)
Science 237, 1039-1041
   Abstract »    PDF »
Activated proto-onc genes: sufficient or necessary for cancer?.
P. Duesberg (1985)
Science 228, 669-677
   Abstract »    PDF »
Primary structure of v-raf: relatedness to the src family of oncogenes.
G. Mark and U. Rapp (1984)
Science 224, 285-289
   Abstract »    PDF »


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