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Science 17 February 1984:
Vol. 223. no. 4637, pp. 653 - 661
DOI: 10.1126/science.6320365
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Articles

Science, Vol 223, Issue 4637, 653-661
Copyright © 1984 by American Association for the Advancement of Science

articles

The molecular basis of neuronal excitability

WA Catterall

Neurons process and transmit information in the form of electrical signals. Their electrical excitability is due to the presence of voltage-sensitive ion channels in the neuronal plasma membrane. In recent years, the voltage-sensitive sodium channel of mammalian brain has become the first of these important neuronal components to be studied at the molecular level. This article describes the distribution of sodium channels among the functional compartments of the neuron and reviews work leading to the identification, purification, and characterization of this membrane glycoprotein.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Overview of Molecular Relationships in the Voltage-Gated Ion Channel Superfamily.
F. H. Yu, V. Yarov-Yarovoy, G. A. Gutman, and W. A. Catterall (2005)
Pharmacol. Rev. 57, 387-395
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Sodium Channel Inactivation: Molecular Determinants and Modulation.
W. Ulbricht (2005)
Physiol Rev 85, 1271-1301
   Abstract »    Full Text »    PDF »
The VGL-Chanome: A Protein Superfamily Specialized for Electrical Signaling and Ionic Homeostasis.
F. H. Yu and W. A. Catterall (2004)
Sci. STKE 2004, re15
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Developmental expression of the novel voltage-gated sodium channel auxiliary subunit {beta}3, in rat CNS.
B S Shah, E B Stevens, R D Pinnock, A K Dixon, and K Lee (2001)
J. Physiol. 534, 763-776
   Abstract »    Full Text »    PDF »
Functional Roles of the Extracellular Segments of the Sodium Channel alpha Subunit in Voltage-dependent Gating and Modulation by beta 1 Subunits.
Y. Qu, J. C. Rogers, S.-F. Chen, K. A. McCormick, T. Scheuer, and W. A. Catterall (1999)
J. Biol. Chem. 274, 32647-32654
   Abstract »    Full Text »    PDF »
Identification of an intracellular peptide segment involved in sodium channel inactivation.
P. Vassilev, T Scheuer, and W. Catterall (1988)
Science 241, 1658-1661
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Rhododendrons, Mountain Laurel, and Mad Honey.
K. F. Lampe (1988)
JAMA 259, 2009
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Multiple calcium channels and neuronal function.
R. Miller (1987)
Science 235, 46-52
   Abstract »    PDF »
Defense strategies against hypoxia and hypothermia.
P. Hochachka (1986)
Science 231, 234-241
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Science. ISSN 0036-8075 (print), 1095-9203 (online)