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Science 10 February 1984:
Vol. 223. no. 4636, pp. 607 - 609
DOI: 10.1126/science.6420888
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Articles

Science, Vol 223, Issue 4636, 607-609
Copyright © 1984 by American Association for the Advancement of Science

articles

Prolongation of rat islet allograft survival by direct ultraviolet irradiation of the graft

H Lau, K Reemtsma, and MA Hardy

Ultraviolet irradiation of rat dendritic cells completely abrogated their allostimulatory capacity in a mixed lymphocyte reaction. Rat islets of Langerhans similarly irradiated remained hormonally functional when transplanted into syngeneic diabetic rats. Allogeneic transplantation across a major histocompatibility barrier of islets initially treated in vitro with ultraviolet irradiation resulted in prolonged allograft survival without the use of any immunosuppressive agents.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Resolving the Conundrum of Islet Transplantation by Linking Metabolic Dysregulation, Inflammation, and Immune Regulation.
X. Huang, D. J. Moore, R. J. Ketchum, C. S. Nunemaker, B. Kovatchev, A. L. McCall, and K. L. Brayman (2008)
Endocr. Rev. 29, 603-630
   Abstract »    Full Text »    PDF »
Tolerance to Antigen-Presenting Cell-Depleted Islet Allografts Is CD4 T Cell Dependent.
M. Coulombe, H. Yang, L. A. Wolf, and R. G. Gill (1999)
J. Immunol. 162, 2503-2510
   Abstract »    Full Text »    PDF »
Induction of donor-specific unresponsiveness by intrathymic islet transplantation.
A. Posselt, C. Barker, J. Tomaszewski, J. Markmann, M. Choti, and A Naji (1990)
Science 249, 1293-1295
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)