Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 10 February 1984:
Vol. 223. no. 4636, pp. 586 - 589
DOI: 10.1126/science.6607531
Prev | Table of Contents | Next

Articles

Science, Vol 223, Issue 4636, 586-589
Copyright © 1984 by American Association for the Advancement of Science

articles

Phosphorylation events during Mullerian duct regression

JM Hutson, ME Fallat, S Kamagata, PK Donahoe, and GP Budzik

Regression of the fetal rat Mullerian duct in vitro was stimulated by sodium fluoride in the absence of Mullerian inhibiting substance. The action of Mullerian inhibiting substance was inhibited by sodium vanadate, adenosine 5'-triphosphate, and several related nucleotides in the presence of manganese ions. Epidermal growth factor specifically inhibited the substance, but only with manganese ions present. Insulin, platelet-derived growth factor, and nerve growth factor had no effect. These results suggest that dephosphorylation of membrane proteins mediates the action of Mullerian inhibiting substance.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Development of Mullerian Inhibiting Substance as an Anti-cancer Drug.
R.L. Cate, E.G. Ninfa, D.J. Pratt, D.T. MacLaughlin, and P.K. Donahoe (1986)
Cold Spring Harb Symp Quant Biol 51, 641-647
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)