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Science 10 February 1984:
Vol. 223. no. 4636, pp. 559 - 563
DOI: 10.1126/science.6607530
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Articles

Science, Vol 223, Issue 4636, 559-563
Copyright © 1984 by American Association for the Advancement of Science

articles

Chromosome 4 Jt gene controls murine T cell surface I-J expression

CE Hayes, KK Klyczek, DP Krum, RM Whitcomb, DA Hullett, and H Cantor

Data are presented suggesting a resolution to the paradox concerning the murine response subregion I-J, which encodes a suppressor T cell marker. The controversy arose when sequences corresponding to I-J DNA were not found in the central immune response region described by immunogeneticists. New evidence is presented that T cell surface I-J expression results from the action of at least two complementing genes. One gene is within the H-2 region on chromosome 17; the second gene, termed Jt, is on chromosome 4. The two recombinant mouse strains B10.A(3R) and B10.A(5R) originally used to define the I-J subregion apparently differ not within the H-2 region but elsewhere.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Molecular analysis of the hotspot of recombination in the murine major histocompatibility complex.
J. Kobori, E Strauss, K Minard, and L Hood (1986)
Science 234, 173-179
   Abstract »    PDF »
Tracking the lost I-J suppressor region.
J. Marx (1984)
Science 223, 573-574
   PDF »


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