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Science 3 February 1984:
Vol. 223. no. 4635, pp. 450 - 455
DOI: 10.1126/science.6197756
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Articles

Science, Vol 223, Issue 4635, 450-455
Copyright © 1984 by American Association for the Advancement of Science

articles

A replication cycle for viroids and other small infectious RNA's

AD Branch and HD Robertson

Experimental data concerning viroid-specific nucleic acids accumulating in tomato plants establish, together with earlier studies, the major features of a replication cycle for viroid RNA in plant cells. Many features of this pathway, which involves multimeric strands of both polarities, may be shared by other small infectious RNA's including certain satellite RNA's and "virusoid" RNA's which replicate in conjunction with conventional plant viruses. The presence, in host plans, of an elaborate machinery for replicating these disease agents suggests a role for endogenous small RNA's in cellular development.


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A. Branch, B. Benenfeld, B. Baroudy, F. Wells, J. Gerin, and H. Robertson (1989)
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Reversible cleavage and ligation of hepatitis delta virus RNA.
H. Wu and M. Lai (1989)
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Viroid-induced phosphorylation of a host protein related to a dsRNA-dependent protein kinase.
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The chemistry of self-splicing RNA and RNA enzymes.
T. Cech (1987)
Science 236, 1532-1539
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Structural and Ionic Requirements for Self-cleavage of Virusoid RNAs and trans Self-cleavage of Viroid RNA.
A.C. Forster, A.C. Jeffries, C.C. Sheldon, and R.H. Symons (1987)
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Transcripts of Newt Satellite DNA Self-cleave In Vitro.
L.M. Epstein and J.G. Gall (1987)
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Autolytic Processing of Dimeric Plant Virus Satellite RNA.
G. A. PRODY, J. T. BAKOS, J. M. BUZAYAN, I. R. SCHNEIDER, and G. BRUENING (1986)
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Oligomerization of intervening sequence RNA molecules in the absence of proteins.
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