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Science 27 January 1984:
Vol. 223. no. 4634, pp. 400 - 403
DOI: 10.1126/science.6362007
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Articles

Science, Vol 223, Issue 4634, 400-403
Copyright © 1984 by American Association for the Advancement of Science

articles

Plasmodium falciparum maturation abolishes physiologic red cell deformability

HA Cranston, CW Boylan, GL Carroll, SP Sutera, Williamson JR, IY Gluzman, and DJ Krogstad

Normal red cells deform markedly as they pass through the spleen and the peripheral capillaries. In these studies, the effects of Plasmodium falciparum infection and maturation on the deformability of parasitized red cells exposed to fluid shear stress in vitro were examined by means of a rheoscope. Red cells containing the early (ring) erythrocytic stage of the parasite have impaired deformability at physiologic shear stresses, and recover their normal shape more slowly. Red cells containing more mature parasites (trophozoites or schizonts) exhibit no deformation under the same conditions. These results provide a mechanism to explain the ability of the spleen to remove parasitized red cells from the circulation of both immune and nonimmune hosts.


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