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Science 27 January 1984:
Vol. 223. no. 4634, pp. 364 - 370
DOI: 10.1126/science.6197754
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Articles

Science, Vol 223, Issue 4634, 364-370
Copyright © 1984 by American Association for the Advancement of Science

articles

Major pol gene progenitors in the evolution of oncoviruses

IM Chiu, R Callahan, Tronick SR, J Schlom, and SA Aaronson

The genetic relationships among molecularly cloned prototype viruses representing all of the major oncovirus genera were investigated by molecular hybridization and nucleotide sequence analysis. One of the major progenitors of the pol genes of such viruses gives rise to mammalian type C viruses and another gives rise to type A, B, D, and avian type C oncoviruses. Evidence of unusual patterns of homology among the env genes of mammalian type C and D oncoviruses illustrates that genetic interactions between their progenitors contributed to the evolution of oncoviruses.


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