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Science 20 January 1984:
Vol. 223. no. 4633, pp. 293 - 296
DOI: 10.1126/science.6422552
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Articles

Science, Vol 223, Issue 4633, 293-296
Copyright © 1984 by American Association for the Advancement of Science

articles

Neuromagnetic evidence of spatially distributed sources underlying epileptiform spikes in the human brain

DS Barth, W Sutherling, J Engle Jr, and J Beatty

Neuromagnetic measurements were performed on 17 subjects with focal seizure disorders. In all of the subjects, the interictal spike in the scalp electroencephalogram was associated with an orderly extracranial magnetic field pattern. In eight of these subjects, multiple current sources underlay the magnetic spike complex. The multiple sources within a given subject displayed a fixed chronological sequence of discharge, demonstrating a high degree of spatial and temporal organization within the interictal focus.


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