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Science 20 January 1984:
Vol. 223. no. 4633, pp. 291 - 293
DOI: 10.1126/science.6608148
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Articles

Science, Vol 223, Issue 4633, 291-293
Copyright © 1984 by American Association for the Advancement of Science

articles

External imaging of cerebral muscarinic acetylcholine receptors

WC Eckelman, RC Reba, WJ Rzeszotarski, RE Gibson, T Hill, BL Holman, T Budinger, JJ Conklin, R Eng, and MP Grissom

A radioiodinated ligand that binds to muscarinic acetylcholine receptors was shown to distribute in the brain by a receptor-mediated process. With single-photon-emission imaging techniques, radioactivity was detected in the cerebrum but not in the cerebellum, whereas with a flow-limited radiotracer, radioactivity was detected in cerebrum and cerebellum. Single-photon-emission computed tomography showed good definition of the caudate putamen and cortex in man.


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