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Science 13 January 1984:
Vol. 223. no. 4632, pp. 169 - 171
DOI: 10.1126/science.6318317
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Articles

Science, Vol 223, Issue 4632, 169-171
Copyright © 1984 by American Association for the Advancement of Science

articles

Nicotine is chemotactic for neutrophils and enhances neutrophil responsiveness to chemotactic peptides

N Totti 3rd, KT McCusker, EJ Campbell, GL Griffin, and RM Senior

Neutrophils contribute to chronic bronchitis and pulmonary emphysema associated with cigarette smoking. Nicotine was found to be chemotactic for human neutrophils but not monocytes, with a peak activity at approximately 31 micromolar. In lower concentrations (comparable to those in smokers' plasma), nicotine enhanced the response of neutrophils to two chemotactic peptides. In contrast to most other chemoattractants for neutrophils, however, nicotine did not affect degranulation or superoxide production. Nicotine thus may promote inflammation and consequent lung injury in smokers.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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J.-M. Tournier, K. Maouche, C. Coraux, J.-M. Zahm, I. Cloez-Tayarani, B. Nawrocki-Raby, A. Bonnomet, H. Burlet, F. Lebargy, M. Polette, et al. (2006)
Am. J. Pathol. 168, 55-68
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The Ras/Raf-1/MEK1/ERK Signaling Pathway Coupled to Integrin Expression Mediates Cholinergic Regulation of Keratinocyte Directional Migration.
A. I. Chernyavsky, J. Arredondo, E. Karlsson, I. Wessler, and S. A. Grando (2005)
J. Biol. Chem. 280, 39220-39228
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Differential regulation of keratinocyte chemokinesis and chemotaxis through distinct nicotinic receptor subtypes.
A. I. Chernyavsky, J. Arredondo, L. M. Marubio, and S. A. Grando (2004)
J. Cell Sci. 117, 5665-5679
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Nicotine induces human neutrophils to produce IL-8 through the generation of peroxynitrite and subsequent activation of NF-{kappa}B.
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Selectin-dependent rolling and adhesion of leukocytes in nicotine-exposed microvessels of lung allografts.
L. Sikora, S. P. Rao, and P. Sriramarao (2003)
Am J Physiol Lung Cell Mol Physiol 285, L654-L663
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Nicotine Strongly Activates Dendritic Cell-Mediated Adaptive Immunity: Potential Role for Progression of Atherosclerotic Lesions.
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Circulation 107, 604-611
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Increased Expression of Transforming Growth Factor-{beta}1 in Small Airway Epithelium from Tobacco Smokers and Patients with Chronic Obstructive Pulmonary Disease (COPD).
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Am. J. Respir. Crit. Care Med. 163, 1476-1483
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Interferon {{gamma}} Induction of Pulmonary Emphysema in the Adult Murine Lung.
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J. Exp. Med. 192, 1587-1600
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Increased expression of inflammatory mediators in small-airway epithelium from tobacco smokers.
H. Takizawa, M. Tanaka, K. Takami, T. Ohtoshi, K. Ito, M. Satoh, Y. Okada, F. Yamasawa, and A. Umeda (2000)
Am J Physiol Lung Cell Mol Physiol 278, L906-L913
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Chronic Obstructive Pulmonary Disease . Inflammation of Small Airways and Lung Parenchyma.
M. G. COSIO and A. GUERASSIMOV (1999)
Am. J. Respir. Crit. Care Med. 160, S21-25
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Neutrophils and Protease/Antiprotease Imbalance.
R. A. STOCKLEY (1999)
Am. J. Respir. Crit. Care Med. 160, S49-52
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Chlorination of Guanosine and Other Nucleosides by Hypochlorous Acid and Myeloperoxidase of Activated Human Neutrophils. CATALYSIS BY NICOTINE AND TRIMETHYLAMINE.
M. Masuda, T. Suzuki, M. D. Friesen, J.-L. Ravanat, J. Cadet, B. Pignatelli, H. Nishino, and H. Ohshima (2001)
J. Biol. Chem. 276, 40486-40496
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