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Science 6 January 1984:
Vol. 223. no. 4631, pp. 61 - 63
DOI: 10.1126/science.6140757
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Articles

Science, Vol 223, Issue 4631, 61-63
Copyright © 1984 by American Association for the Advancement of Science

articles

Coexistence of acetylcholinesterase and somatostatin-immunoreactivity in neurons cultured from rat cerebrum

Delfs JR, CH Zhu, and MA Dichter

Cultures derived from rat cerebral hemispheres were sequentially stained for acetylcholinesterase activity and for either somatostatin-like immunoreactivity or cholecystokinin-like immunoreactivity. Somatostatin-like immunoreactivity was found to coexist with acetylcholinesterase activity in individual neurons of several morphological subtypes, but cholecystokinin-like immunoreactivity and acetycholinesterase activity were never seen in the same neurons. These findings suggest a specific anatomical association, perhaps even an overlap, of the cholinergic and somatostatinergic systems in the mammalian cerebrum, and indicate that the combined deficiencies of somatostatin and cholinergic markers in Alzheimer's dementia and senile dementia of the Alzheimer type may be of pathophysiological importance.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cerebrospinal Fluid Somatostatin and Neuropeptide Y: Concentrations in Aging and in Dementia of the Alzheimer Type With and Without Extrapyramidal Signs.
J. R. Atack, M. F. Beal, C. May, J. A. Kaye, M. F. Mazurek, A. D. Kay, and S. I. Rapoport (1988)
Arch Neurol 45, 269-274
   Abstract »    PDF »
Cerebrospinal Fluid Vasopressin, Oxytocin, sopressin, Oxytoc in Alzheimer's Diseas{beta}-Endorphin.
M. A. Raskind, i. R. Peskind, T. H. Lampe, S. C. Risse, G. J. Taborsky Jr, and D. Dorsa (1986)
Arch Gen Psychiatry 43, 382-388
   Abstract »    PDF »
Alzheimer's disease: clinical, neuropathologic, neuropsychologic, and brain metabolic findings.
N. R. Cutler and P. K. Narang (1986)
American Journal of Alzheimer's Disease and Other Dementias 1, 16-23
   Abstract »    PDF »
Reduced numbers of somatostatin receptors in the cerebral cortex in Alzheimer's disease.
M. Beal, M. Mazurek, V. Tran, G Chattha, E. Bird, and J. Martin (1985)
Science 229, 289-291
   Abstract »    PDF »
Evidence for cholinergic neurites in senile plaques.
C. Kitt, D. Price, R. Struble, L. Cork, B. Wainer, M. Becher, and W. Mobley (1984)
Science 226, 1443-1445
   Abstract »    PDF »


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