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Science 23 December 1983:
Vol. 222. no. 4630, pp. 1344 - 1346
DOI: 10.1126/science.6658455
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Articles

Science, Vol 222, Issue 4630, 1344-1346
Copyright © 1983 by American Association for the Advancement of Science

articles

Compartmentation of glycolytic and glycogenolytic metabolism in vascular smooth muscle

RM Lynch and RJ Paul

Vascular smooth muscle is characterized by a high rate of aerobic lactate production, which may be altered independently of oxidative phosphorylation. This finding suggested a cytoplasmic compartmentation of metabolism. Exogenous glucose was found to be the sole precursor of aerobic glycolysis under unstimulated conditions. Although tissue depolarization with high K+ resulted in a substantial reduction of endogenous glycogen, exogenous glucose remained the sole precursor of aerobic lactate production. These data showed unequivocally that carbohydrate metabolism is compartmentalized in vascular smooth muscle.


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