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Science 23 December 1983:
Vol. 222. no. 4630, pp. 1334 - 1336
DOI: 10.1126/science.6419346
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Articles

Science, Vol 222, Issue 4630, 1334-1336
Copyright © 1983 by American Association for the Advancement of Science

articles

Estradiol fatty acid esters occur naturally in human blood

L Janocko and RB Hochberg

Treatment of nonpolar ether extracts of human female blood with mild alkali produced more immunoassayable estradiol than the unhydrolyzed extract. Analysis of the serum extracts showed that the substance which released immunoreactive estradiol after hydrolysis has chromatographic properties identical to those of fatty acid esters of estradiol esterified at carbon 17. The physiological role of these previously unknown endogenous esters might be inferred from their structural similarity to synthetic drugs used therapeutically for their prolonged estrogenic action.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Differential Effects of Oral and Transdermal Estradiol Treatment on Circulating Estradiol Fatty Acid Ester Concentrations in Postmenopausal Women.
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J. Clin. Endocrinol. Metab. 88, 588-593
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Lipoprotein-associated estrogens.
M. J Tikkanen, V. Vihma, M. Jauhiainen, A. Hockerstedt, H. Helisten, and M. Kaamanen (2002)
Cardiovasc Res 56, 184-188
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Quantitative Determination of Estradiol Fatty Acid Esters in Human Pregnancy Serum and Ovarian Follicular Fluid.
V. Vihma, H. Adlercreutz, A. Tiitinen, P. Kiuru, K. Wahala, and M. J. Tikkanen (2001)
Clin. Chem. 47, 1256-1262
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Stimulatory Effect of Clofibrate on the Action of Estradiol in the Mammary Gland but Not in the Uterus of Rats.
S. Xu, B. T. Zhu, M. X. Cai, and A. H. Conney (2001)
J. Pharmacol. Exp. Ther. 297, 50-56
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Regiospecific Esterification of Estrogens by Lecithin:Cholesterol Acyltransferase.
S. S. Kanji, W. Kuohung, D. C. Labaree, and R. B. Hochberg (1999)
J. Clin. Endocrinol. Metab. 84, 2481-2488
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Biological Esterification of Steroids.
R. B. Hochberg (1998)
Endocr. Rev. 19, 331-348
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Effect of soybean phytoestrogen intake on low density lipoprotein oxidation resistance.
M. J. Tikkanen, K. Wahala, S. Ojala, V. Vihma, and H. Adlercreutz (1998)
PNAS 95, 3106-3110
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