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Science 16 December 1983:
Vol. 222. no. 4629, pp. 1248 - 1251
DOI: 10.1126/science.6648531
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Articles

Science, Vol 222, Issue 4629, 1248-1251
Copyright © 1983 by American Association for the Advancement of Science

articles

The human gene for the beta subunit of nerve growth factor is located on the proximal short arm of chromosome 1

U Francke, B de Martinville, L Coussens, and A Ullrich

Fragments of the recently cloned human gene for the beta subunit of nerve growth factor (beta-NGF) were used as hybridization probes in analyzing two sets of rodent-human somatic cell hybrids for the presence of human beta-NGF sequences. Results from the first set of hybrids assigned the human beta-NGF gene to chromosome 1 and ruled out the presence of sequences of comparable homology on any other chromosome. With the second set of hybrids, which contained seven different, but overlapping, regions of chromosome 1, the NGF locus was mapped to band 1p22.


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Chromosomal Mapping of Genes Involved in Growth Control.
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Cold Spring Harb Symp Quant Biol 51, 855-866
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Neurotrophic factors.
H Thoenen and D Edgar (1985)
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