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Science 16 December 1983:
Vol. 222. no. 4629, pp. 1246 - 1248
DOI: 10.1126/science.6316506
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Articles

Science, Vol 222, Issue 4629, 1246-1248
Copyright © 1983 by American Association for the Advancement of Science

articles

Ethanol modulation of opiate receptors in cultured neural cells

ME Charness, AS Gordon, and I Diamond

The mouse neuroblastoma-rat glioma hybrid cell line NG108-15 was used to study the acute and chronic interaction of ethanol with intact neural cells. In the short term, ethanol inhibited opiate receptor binding, but after long-term exposure the cells exhibited an apparent adaptive increase in the number of opiate binding sites; this was reversible when ethanol was withdrawn. High concentrations of ethanol (200 mM) increased opiate binding after 18 to 24 hours, whereas lower concentrations (25 to 50 mM) produced similar changes after 2 weeks. This model system has potential for exploring the cellular and molecular mechanisms underlying ethanol intoxication, tolerance, and withdrawal.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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PNAS 105, 12533-12538
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Naltrexone inhibits alcohol-mediated enhancement of HIV infection of T lymphocytes.
X. Wang, S. D. Douglas, J.-S. Peng, D. S. Metzger, C. P. O'Brien, T. Zhang, and W.-Z. Ho (2006)
J. Leukoc. Biol. 79, 1166-1172
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Dopamine D2 Receptor Inhibition of Adenylyl Cyclase Is Abolished by Acute Ethanol but Restored after Chronic Ethanol Exposure (Tolerance).
L. Yao, K. Asai, Z. Jiang, A. Ishii, P. Fan, A. S. Gordon, and I. Diamond (2001)
J. Pharmacol. Exp. Ther. 298, 833-839
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A Double-blind, Placebo-Controlled Study of Oral Nalmefene for Alcohol Dependence.
B. J. Mason, F. R. Salvato, L. D. Williams, E. C. Ritvo, and R. B. Cutler (1999)
Arch Gen Psychiatry 56, 719-724
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