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Science 9 December 1983:
Vol. 222. no. 4628, pp. 1137 - 1139
DOI: 10.1126/science.6648526
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Articles

Science, Vol 222, Issue 4628, 1137-1139
Copyright © 1983 by American Association for the Advancement of Science

articles

Dynorphin-A-(1-8) is contained within vasopressin neurosecretory vesicles in rat pituitary

MH Whitnall, H Gainer, BM Cox, and CJ Molineaux

Dynorphin-A-(1-8), an opioid peptide widely distributed in the rat central nervous system, is present in vasopressin-containing neurosecretory cells terminating in the neural lobe of the pituitary. Electron microscopic immunocytochemistry reveals that dynorphin-A-(1-8) is contained within the same neurosecretory vesicles as vasopressin and vasopressin-associated neurophysin in the neural lobe of the rat. The results indicate that dynorphin may be released in the pituitary concomitantly with vasopressin during the antidiuretic response.


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